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GNB4

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNB4

Identifiers

Aliases

GNB4, CMTD1F, G protein subunit beta 4, HG2B

External IDs

OMIM:610863;MGI:104581;HomoloGene:69140;GeneCards:GNB4;OMA:GNB4 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q26.33	Start	179,396,088bp^[1]
Band	3q26.33	End	179,451,476bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 A3	Start	32,634,481bp^[2]
Band	3\|3 A3	End	32,670,734bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of arm

secondary oocyte

skin of thigh

tibia

skin of hip

visceral pleura

parietal pleura

synovial membrane

saphenous vein

trigeminal ganglion

Top expressed in

semi-lunar valve

ascending aorta

lumbar spinal ganglion

aortic valve

dermis

primary oocyte

vas deferens

tunica media of zone of aorta

superior cervical ganglion

yolk sac

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein-containing complex binding signal transducer activity
Cellular component	myelin sheath lysosomal membrane extracellular exosome cytosol
Biological process	cellular response to glucagon stimulus substantia nigra development signal transduction protein folding
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


59345


14696

Ensembl


ENSG00000114450


ENSMUSG00000027669

UniProt


Q9HAV0


P29387

RefSeq (mRNA)


NM_021629


NM_013531 NM_001348062 NM_001348104 NM_001348105

RefSeq (protein)


NP_067642


NP_038559 NP_001334991 NP_001335033 NP_001335034

Location (UCSC)

Chr 3: 179.4 – 179.45 Mb

Chr 3: 32.63 – 32.67 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein subunit beta-4 is aprotein that in humans is encoded by theGNB4gene.^[5]^[6]^[7]

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000114450 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000027669 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Downes GB, Gautam N (Mar 2000). "The G protein subunit gene families".Genomics.62 (3):544–52.doi:10.1006/geno.1999.5992.PMID 10644457.
^Ruiz-Velasco V, Ikeda SR, Puhl HL (Feb 2002). "Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit".Physiol Genomics.8 (1):41–50.doi:10.1152/physiolgenomics.00085.2001.PMID 11842130.
^^a ^b"Entrez Gene: GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4".

Pietruck F, Moritz A, Montemurro M, et al. (1996). "Selectively enhanced cellular signaling by Gi proteins in essential hypertension. G alpha i2, G alpha i3, G beta 1, and G beta 2 are not mutated".Circ. Res.79 (5):974–83.doi:10.1161/01.res.79.5.974.PMID 8888689.
Asano T, Morishita R, Ueda H, Kato K (1999)."Selective association of G protein beta(4) with gamma(5) and gamma(12) subunits in bovine tissues".J. Biol. Chem.274 (30):21425–9.doi:10.1074/jbc.274.30.21425.PMID 10409705.
Huang L, Shanker YG, Dubauskaite J, et al. (2000). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium".Nat. Neurosci.2 (12):1055–62.doi:10.1038/15981.PMID 10570481.S2CID 24494794.
Evanko DS, Thiyagarajan MM, Siderovski DP, Wedegaertner PB (2001)."Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq".J. Biol. Chem.276 (26):23945–53.doi:10.1074/jbc.M101154200.PMID 11294873.
Huang L, Max M, Margolskee RF, et al. (2003). "G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells".J. Comp. Neurol.455 (1):1–10.doi:10.1002/cne.10396.PMID 12454992.S2CID 22270368.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Cuello F, Schulze RA, Heemeyer F, et al. (2003)."Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta".J. Biol. Chem.278 (9):7220–6.doi:10.1074/jbc.M210304200.PMID 12486123.
Sprague RS, Bowles EA, Olearczyk JJ, et al. (2003). "The role of G protein beta subunits in the release of ATP from human erythrocytes".J. Physiol. Pharmacol.53 (4 Pt 1):667–74.PMID 12512701.
Rosskopf D, Nikula C, Manthey I, et al. (2003). "The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction".FEBS Lett.544 (1–3):27–32.doi:10.1016/S0014-5793(03)00441-1.PMID 12782285.S2CID 80919988.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.

v t e PDB gallery
1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA 1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN 1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA 1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS 1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND 1omw: Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits 1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN 1xhm: The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer 2bcj: Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits 2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

PDB gallery

1a0r: HETEROTRIMERIC COMPLEX OF PHOSDUCIN/TRANSDUCIN BETA-GAMMA
1b9x: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN
1b9y: STRUCTURAL ANALYSIS OF PHOSDUCIN AND ITS PHOSPHORYLATION-REGULATED INTERACTION WITH TRANSDUCIN BETA-GAMMA
1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
1omw: Crystal Structure of the complex between G Protein-Coupled Receptor Kinase 2 and Heterotrimeric G Protein beta 1 and gamma 2 subunits
1tbg: BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
1xhm: The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
2bcj: Crystal Structure of G Protein-Coupled Receptor Kinase 2 in Complex with Galpha-q and Gbetagamma Subunits
2trc: PHOSDUCIN/TRANSDUCIN BETA-GAMMA COMPLEX

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase