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GNAT3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNAT3

Identifiers

Aliases

GNAT3, GDCA, G protein subunit alpha transducin 3, HG1E

External IDs

OMIM:139395;MGI:3588268;HomoloGene:24284;GeneCards:GNAT3;OMA:GNAT3 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q21.11	Start	80,458,635bp^[1]
Band	7q21.11	End	80,512,064bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 A3	Start	18,167,547bp^[2]
Band	5\|5 A3	End	18,224,832bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

gonad

tibialis anterior muscle

duodenum

abdominal wall

mucosa of small intestine

prefrontal cortex

right lobe of thyroid gland

left lobe of thyroid gland

large intestine

Top expressed in

mucosa of large intestine

intestinal epithelium

tongue

epithelium of colon

mucosa of small intestine

neural layer of retina

vallate papilla

secondary oocyte

epithelium of small intestine

white adipose tissue

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	signal transducer activity metal ion binding nucleotide binding guanyl nucleotide binding G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity
Cellular component	acrosomal vesicle cytoplasm axoneme heterotrimeric G-protein complex apical plasma membrane plasma membrane photoreceptor outer segment photoreceptor inner segment protein-containing complex
Biological process	signal transduction sensory perception of umami taste response to nicotine adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway sensory perception of bitter taste sensory perception of taste sensory perception of sweet taste protein folding detection of chemical stimulus involved in sensory perception of bitter taste G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


346562


242851

Ensembl


ENSG00000214415


ENSMUSG00000028777

UniProt


A8MTJ3


Q3V3I2

RefSeq (mRNA)


NM_001102386


NM_001081143

RefSeq (protein)


NP_001095856


NP_001074612

Location (UCSC)

Chr 7: 80.46 – 80.51 Mb

Chr 5: 18.17 – 18.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-3, also known asgustducin alpha-3 chain, is aprotein subunit that in humans is encoded by theGNAT3gene.^[5]

Gustducin alpha-3 chain is a subunit of theheterotrimeric G protein gustducin that is responsible forbasic taste.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000214415 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000028777 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: guanine nucleotide binding protein".

Oldham WM, Van Eps N, Preininger AM, et al. (2006). "Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins".Nat. Struct. Mol. Biol.13 (9):772–7.doi:10.1038/nsmb1129.PMID 16892066.S2CID 290532.
Scherer SW, Cheung J, MacDonald JR, et al. (2003)."Human chromosome 7: DNA sequence and biology".Science.300 (5620):767–72.Bibcode:2003Sci...300..767S.doi:10.1126/science.1083423.PMC 2882961.PMID 12690205.
Rozengurt N, Wu SV, Chen MC, et al. (2006). "Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon".Am. J. Physiol. Gastrointest. Liver Physiol.291 (5): G792-802.doi:10.1152/ajpgi.00074.2006.PMID 16728727.
Huang L, Shanker YG, Dubauskaite J, et al. (1999). "Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium".Nat. Neurosci.2 (12):1055–62.doi:10.1038/15981.PMID 10570481.S2CID 24494794.
Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424 (6945):157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID 12853948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors".Mol. Biotechnol.39 (3):239–64.doi:10.1007/s12033-008-9031-1.PMID 18240029.S2CID 45173229.
Margolskee RF, Dyer J, Kokrashvili Z, et al. (2007)."T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1".Proc. Natl. Acad. Sci. U.S.A.104 (38):15075–80.Bibcode:2007PNAS..10415075M.doi:10.1073/pnas.0706678104.PMC 1986615.PMID 17724332.
Takami S, Getchell TV, McLaughlin SK, et al. (1994). "Human taste cells express the G protein alpha-gustducin and neuron-specific enolase".Brain Res. Mol. Brain Res.22 (1–4):193–203.doi:10.1016/0169-328X(94)90047-7.PMID 8015379.
Jang HJ, Kokrashvili Z, Theodorakis MJ, et al. (2007)."Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1".Proc. Natl. Acad. Sci. U.S.A.104 (38):15069–74.Bibcode:2007PNAS..10415069J.doi:10.1073/pnas.0706890104.PMC 1986614.PMID 17724330.
Li X, Staszewski L, Xu H, et al. (2002)."Human receptors for sweet and umami taste".Proc. Natl. Acad. Sci. U.S.A.99 (7):4692–6.Bibcode:2002PNAS...99.4692L.doi:10.1073/pnas.072090199.PMC 123709.PMID 11917125.
Fehr J, Meyer D, Widmayer P, et al. (2007). "Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa".J. Comp. Physiol. A.193 (1):21–34.doi:10.1007/s00359-006-0168-8.PMID 17021831.S2CID 25762931.
Lambright DG, Noel JP, Hamm HE, Sigler PB (1994). "Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein".Nature.369 (6482):621–8.Bibcode:1994Natur.369..621L.doi:10.1038/369621a0.PMID 8208289.S2CID 4238569.

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase