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GNAT2

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
GNAT2
Identifiers
AliasesGNAT2, ACHM4, GNATC, G protein subunit alpha transducin 2, HG1D
External IDsOMIM:139340;MGI:95779;HomoloGene:21092;GeneCards:GNAT2;OMA:GNAT2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GNAT2
Genomic location for GNAT2
Band1p13.3Start109,603,091bp[1]
End109,619,929bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for GNAT2
Genomic location for GNAT2
Band3 F2.3|3 46.83 cMStart108,000,105bp[2]
End108,008,748bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • gonad

  • secondary oocyte

  • testicle

  • apex of heart

  • monocyte

  • islet of Langerhans

  • stromal cell of endometrium

  • blood

  • granulocyte
Top expressed in
  • neural layer of retina

  • retinal pigment epithelium

  • epithelium of lens

  • pineal gland

  • islet of Langerhans

  • zygote

  • primary oocyte

  • embryo

  • secondary oocyte

  • embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2780

14686

Ensembl

ENSG00000134183

ENSMUSG00000009108

UniProt

P19087

P50149

RefSeq (mRNA)

NM_005272
NM_001377295
NM_001379232

NM_008141

RefSeq (protein)

NP_005263
NP_001364224
NP_001366161

NP_032167

Location (UCSC)Chr 1: 109.6 – 109.62 MbChr 3: 108 – 108.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-2 is aprotein that in humans is encoded by theGNAT2gene.[5][6]

Function

[edit]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling ofrhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits inrods andcones are encoded by separate genes. This gene encodes the alpha subunit in cones.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000134183 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000009108 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Morris TA, Fong SL (Oct 1993). "Characterization of the gene encoding human cone transducin alpha-subunit (GNAT2)".Genomics.17 (2):442–8.doi:10.1006/geno.1993.1345.PMID 8406495.
  6. ^ab"Entrez Gene: GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2".

Further reading

[edit]

External links

[edit]
MAP
Calcium
G protein
Heterotrimeric
cAMP:
cGMP:
Monomeric
Cyclin
Lipid
Otherprotein kinase
Serine/threonine:
Tyrosine:
Serine/threonine/tyrosine
Arginine
Otherprotein phosphatase
Serine/threonine:
Tyrosine:
both:
Apoptosis
GTP-binding protein regulators
Other
3.6.1
3.6.2
3.6.3-4:ATPase
3.6.3
Cu++ (3.6.3.4)
Ca+ (3.6.3.8)
Na+/K+ (3.6.3.9)
H+/K+ (3.6.3.10)
OtherP-type ATPase
3.6.4
3.6.5:GTPase
3.6.5.1:Heterotrimeric G protein
3.6.5.2:Small GTPase >Ras superfamily
3.6.5.3:Protein-synthesizing GTPase
3.6.5.5-6:Polymerization motors


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