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GNAT1

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GNAT1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3RBQ

Identifiers

Aliases

GNAT1, CSNBAD3, GBT1, GNATR, CSNB1G, G protein subunit alpha transducin 1, HG1F

External IDs

OMIM:139330;MGI:95778;HomoloGene:20084;GeneCards:GNAT1;OMA:GNAT1 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	50,191,610bp^[1]
Band	3p21.31	End	50,197,696bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 F1\|9 58.86 cM	Start	107,551,673bp^[2]
Band	9 F1\|9 58.86 cM	End	107,556,911bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

choroid

right lobe of liver

retina

retinal pigment epithelium

mucosa of nose

right testis

left testis

prefrontal cortex

spinal cord

C1 segment

Top expressed in

blastocyst

neural layer of retina

retinal pigment epithelium

epithelium of lens

iris

morula

embryo

ciliary body

outer nuclear layer

conjunctival fornix

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GDP binding metal ion binding acyl binding guanyl nucleotide binding G protein-coupled receptor binding protein kinase binding signal transducer activity GTP binding G-protein beta/gamma-subunit complex binding GTPase activity
Cellular component	cytoplasm cytosol plasma membrane photoreceptor connecting cilium soma apical plasma membrane photoreceptor disc membrane photoreceptor outer segment membrane photoreceptor outer segment heterotrimeric G-protein complex photoreceptor inner segment membrane cell projection
Biological process	response to light stimulus response to stimulus regulation of rhodopsin mediated signaling pathway detection of chemical stimulus involved in sensory perception of bitter taste detection of light stimulus involved in visual perception retina development in camera-type eye eye photoreceptor cell development response to light intensity negative regulation of cyclic-nucleotide phosphodiesterase activity cell population proliferation positive regulation of cyclic-nucleotide phosphodiesterase activity phototransduction cellular response to electrical stimulus signal transduction protein folding adenylate cyclase-modulating G protein-coupled receptor signaling pathway phototransduction, visible light rhodopsin mediated signaling pathway sensory perception of umami taste visual perception G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2779


14685

Ensembl


ENSG00000114349


ENSMUSG00000034837

UniProt


P11488


P20612

RefSeq (mRNA)


NM_000172 NM_144499


NM_008140

RefSeq (protein)


NP_000163 NP_653082


NP_032166

Location (UCSC)

Chr 3: 50.19 – 50.2 Mb

Chr 9: 107.55 – 107.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(t) subunit alpha-1 is aprotein that in humans is encoded by theGNAT1gene.^[5]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling ofrhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits inrods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000114349 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000034837 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1".

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:P11488 (Guanine nucleotide-binding protein G(t) subunit alpha-1) at thePDBe-KB.

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase

Apoptosis

seeapoptosis signaling pathway

GTP-binding protein regulators

seeGTP-binding protein regulators

Other

see alsodeficiencies of intracellular signaling peptides and proteins

v t e PDB gallery
1fqj: CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)] 1fqk: CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)] 1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS 1tad: GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- 1tag: STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN 1tnd: THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

PDB gallery

1fqj: CRYSTAL STRUCTURE OF THE HETEROTRIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, THE GAMMA SUBUNIT OF PHOSPHODIESTERASE AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(PDEGAMMA)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
1fqk: CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]
1got: HETEROTRIMERIC COMPLEX OF A GT-ALPHA/GI-ALPHA CHIMERA AND THE GT-BETA-GAMMA SUBUNITS
1tad: GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4-
1tag: STRUCTURAL DETERMINANTS FOR ACTIVATION OF THE ALPHA-SUBUNIT OF A HETEROTRIMERIC G PROTEIN
1tnd: THE 2.2 ANGSTROMS CRYSTAL STRUCTURE OF TRANSDUCIN-ALPHA COMPLEXED WITH GTP GAMMA S

Hydrolases:acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4:ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B
Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2
Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4
H+/K+ (3.6.3.10)	ATP4A
OtherP-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5:GTPase

3.6.5.1:Heterotrimeric G protein	G_αs G_olf G_αi GNAI1 GNAI2 GNAI3 Transducin GNAT1 GNAT2 Gustducin GNAT3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13
3.6.5.2:Small GTPase >Ras superfamily	Rho family of GTPases:Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other:Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK
3.6.5.3:Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic
3.6.5.5-6:Polymerization motors	dynamin superfamily Dynamin Guanylate-binding protein Mitofusin-1 MX1 andMX2 OPA1 Tubulin

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