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GNAI1

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From Wikipedia, the free encyclopedia

Protein-coding gene in humans

GNAI1

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1KJY,1Y3A,2G83,2GTP,2IK8,2OM2,2XNS,3ONW,3QE0,3QI2,3UMR,3UMS,4G5Q,5JS7,5JS8

Identifiers

Aliases

GNAI1, Gi, G protein subunit alpha i1, HG1B, NEDHISB

External IDs

OMIM:139310;MGI:95771;HomoloGene:74417;GeneCards:GNAI1;OMA:GNAI1 - orthologs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q21.11	Start	79,768,028bp^[1]
Band	7q21.11	End	80,226,181bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 A3\|5 8.16 cM	Start	18,470,133bp^[2]
Band	5 A3\|5 8.16 cM	End	18,565,353bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus callosum

inferior ganglion of vagus nerve

pars reticulata

subthalamic nucleus

germinal epithelium

C1 segment

Pons

oocyte

secondary oocyte

superior vestibular nucleus

Top expressed in

substantia nigra

lateral septal nucleus

subiculum

barrel cortex

sciatic nerve

nucleus accumbens

white adipose tissue

Region I of hippocampus proper

cerebellar vermis

lobe of cerebellum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	GTPase activating protein binding nucleotide binding G-protein beta/gamma-subunit complex binding GDP binding G protein-coupled serotonin receptor binding signal transducer activity metal ion binding protein binding guanyl nucleotide binding G protein-coupled receptor binding GTP binding magnesium ion binding GTPase activity
Cellular component	cytoplasm centrosome membrane plasma membrane intracellular anatomical structure microtubule organizing center lysosomal membrane midbody heterotrimeric G-protein complex membrane raft extracellular exosome cytoskeleton nucleus nucleolus cell cortex region cell cortex protein-containing complex
Biological process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to peptide hormone negative regulation of synaptic transmission cell division cell cycle signal transduction regulation of cAMP-mediated signaling cellular response to forskolin protein folding regulation of mitotic spindle organization positive regulation of protein localization to cell cortex transport G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2770


14677

Ensembl


ENSG00000127955


ENSMUSG00000057614

UniProt


P63096


B2RSH2

RefSeq (mRNA)


NM_002069 NM_001256414


NM_010305

RefSeq (protein)


NP_001243343 NP_002060


NP_034435

Location (UCSC)

Chr 7: 79.77 – 80.23 Mb

Chr 5: 18.47 – 18.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-1 subunit is aprotein that in humans is encoded by theGNAI1gene.^[5]^[6]

Interactive pathway map

[edit]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

[[File:

|alt=Nicotine Activity on Dopaminergic Neurons edit]]

Nicotine Activity on Dopaminergic Neuronsedit

^The interactive pathway map can be edited at WikiPathways:"NicotineDopaminergic_WP1602".

Interactions

[edit]

GNAI1 has been shown tointeract with:

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000127955 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000057614 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (Aug 1987)."Human cDNA clones for an alpha subunit of Gi signal-transduction protein".Proceedings of the National Academy of Sciences of the United States of America.84 (15):5115–9.Bibcode:1987PNAS...84.5115B.doi:10.1073/pnas.84.15.5115.PMC 298804.PMID 3110783.
^"Entrez Gene: GNAI1 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1".
^Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system".Nature Genetics.23 (1):108–12.doi:10.1038/12715.PMID 10471510.S2CID 6604295.
^^a ^bKimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001)."RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity".The Journal of Biological Chemistry.276 (31):29275–81.doi:10.1074/jbc.M103208200.PMID 11387333.
^Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP (Apr 2002). "Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits".Nature.416 (6883):878–81.Bibcode:2002Natur.416..878K.doi:10.1038/416878a.PMID 11976690.S2CID 4406208.
^Woulfe DS, Stadel JM (Jun 1999)."Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP".The Journal of Biological Chemistry.274 (25):17718–24.doi:10.1074/jbc.274.25.17718.PMID 10364213.
^De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996)."GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits".Proceedings of the National Academy of Sciences of the United States of America.93 (26):15203–8.Bibcode:1996PNAS...9315203D.doi:10.1073/pnas.93.26.15203.PMC 26381.PMID 8986788.
^Tall GG, Krumins AM, Gilman AG (Mar 2003)."Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor".The Journal of Biological Chemistry.278 (10):8356–62.doi:10.1074/jbc.M211862200.PMID 12509430.
^Lee MJ, Evans M, Hla T (May 1996)."The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway".The Journal of Biological Chemistry.271 (19):11272–9.doi:10.1074/jbc.271.19.11272.PMID 8626678.

Sidhu A, Niznik HB (Nov 2000). "Coupling of dopamine receptor subtypes to multiple and diverse G proteins".International Journal of Developmental Neuroscience.18 (7):669–77.doi:10.1016/S0736-5748(00)00033-2.PMID 10978845.S2CID 21002590.
Brown EJ, Frazier WA (Mar 2001). "Integrin-associated protein (CD47) and its ligands".Trends in Cell Biology.11 (3):130–5.doi:10.1016/S0962-8924(00)01906-1.PMID 11306274.
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction".Pharmacology & Therapeutics.92 (2–3):179–212.doi:10.1016/S0163-7258(01)00169-3.PMID 11916537.
Jiang M, Pandey S, Tran VT, Fong HK (May 1991)."Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells".Proceedings of the National Academy of Sciences of the United States of America.88 (9):3907–11.Bibcode:1991PNAS...88.3907J.doi:10.1073/pnas.88.9.3907.PMC 51562.PMID 1902575.
Gennity JM, Siess W (Nov 1991)."Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets".The Biochemical Journal.279 (Pt 3):643–50.doi:10.1042/bj2790643.PMC 1151493.PMID 1953657.
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y (May 1988)."Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs".The Journal of Biological Chemistry.263 (14):6656–64.doi:10.1016/S0021-9258(18)68692-2.PMID 2834384.
Bloch DB, Bloch KD, Iannuzzi M, Collins FS, Neer EJ, Seidman JG, Morton CC (Jun 1988)."The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus".American Journal of Human Genetics.42 (6):884–8.PMC 1715192.PMID 3130752.
Nagata K, Katada T, Tohkin M, Itoh H, Kaziro Y, Ui M, Nozawa Y (Sep 1988)."GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin".FEBS Letters.237 (1–2):113–7.doi:10.1016/0014-5793(88)80182-0.PMID 3139448.S2CID 27091750.
Kagimoto S, Yamada Y, Kubota A, Someya Y, Ihara Y, Yasuda K, Kozasa T, Imura H, Seino S, Seino Y (Jul 1994). "Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein".Biochemical and Biophysical Research Communications.202 (2):1188–95.doi:10.1006/bbrc.1994.2054.PMID 7914078.
Nitta K, Uchida K, Kawashima A, Tsutsui T, Ozu H, Naito T, Yumura W, Nihei H (Jan 1994). "Identification of GTP-binding proteins in human glomeruli".Nihon Jinzo Gakkai Shi.36 (1):9–12.PMID 8107314.
Law SF, Zaina S, Sweet R, Yasuda K, Bell GI, Stadel J, Reisine T (Apr 1994). "Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation".Molecular Pharmacology.45 (4):587–90.PMID 8183236.
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (Jun 1993). "Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy".Endocrinology.132 (6):2484–90.doi:10.1210/endo.132.6.8504751.PMID 8504751.
Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G (Jan 1996)."The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families".Proceedings of the National Academy of Sciences of the United States of America.93 (1):116–20.Bibcode:1996PNAS...93..116L.doi:10.1073/pnas.93.1.116.PMC 40189.PMID 8552586.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction".Analytical Biochemistry.236 (1):107–13.doi:10.1006/abio.1996.0138.PMID 8619474.
Lee MJ, Evans M, Hla T (May 1996)."The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway".The Journal of Biological Chemistry.271 (19):11272–9.doi:10.1074/jbc.271.19.11272.PMID 8626678.
De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996)."GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits".Proceedings of the National Academy of Sciences of the United States of America.93 (26):15203–8.Bibcode:1996PNAS...9315203D.doi:10.1073/pnas.93.26.15203.PMC 26381.PMID 8986788.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997)."Large-scale concatenation cDNA sequencing".Genome Research.7 (4):353–8.doi:10.1101/gr.7.4.353.PMC 139146.PMID 9110174.
Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997)."The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro".Proceedings of the National Academy of Sciences of the United States of America.94 (14):7216–20.Bibcode:1997PNAS...94.7216P.doi:10.1073/pnas.94.14.7216.PMC 23796.PMID 9207071.
Shuey DJ, Betty M, Jones PG, Khawaja XZ, Cockett MI (May 1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells".Journal of Neurochemistry.70 (5):1964–72.doi:10.1046/j.1471-4159.1998.70051964.x.PMID 9572280.S2CID 31928913.

Intracellular signaling peptides and proteins

MAP

seeMAP kinase pathway

Calcium

G protein

Heterotrimeric

cAMP:	Heterotrimeric G protein Gs/Gi Adenylate cyclase cAMP 3',5'-cyclic-AMP phosphodiesterase Protein kinase A
cGMP:	Transducin Gustducin Guanylate cyclase cGMP 3',5'-cyclic-GMP phosphodiesterase Protein kinase G
G alpha subunit G_α GNAO1 GNAI1 GNAI2 GNAI3 GNAT1 GNAT2 GNAT3 GNAZ GNAS GNAL GNAQ GNA11 GNA12 GNA13 GNA14 GNA15/GNA16
G beta-gamma complex G_β GNB1 GNB2 GNB3 GNB4 GNB5 G_γ GNGT1 GNGT2 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNG10 GNG11 GNG12 GNG13 BSCL2
G protein-coupled receptor kinase AMP-activated protein kinase

Monomeric

Cyclin

Lipid

Otherprotein kinase

Serine/threonine:	Casein kinase 1 2 eIF-2 kinase EIF2AK3 Glycogen synthase kinase GSK1 GSK2 GSK-3 GSK3A GSK3B IκB kinase CHUK IKK2 IKBKG Interleukin-1 receptor associated kinase IRAK1 IRAK2 IRAK3 IRAK4 Lim kinase LIMK1 LIMK2 p21-activated kinases PAK1 PAK2 PAK3 PAK4 Rho-associated protein kinase ROCK1 ROCK2 Ribosomal s6 kinase RPS6KA1
Tyrosine:	ZAP70 Focal adhesion protein-tyrosine kinase PTK2 PTK2B BTK
Serine/threonine/tyrosine	Dual-specificity kinase DYRK1A DYRK1B DYRK2 DYRK3 DYRK4
Arginine	Arginine kinase McsB

Otherprotein phosphatase

Serine/threonine:	Protein phosphatase 2
Tyrosine:	protein tyrosine phosphatase:Receptor-like protein tyrosine phosphatase Sh2 domain-containing protein tyrosine phosphatase
both:	Dual-specificity phosphatase

Apoptosis

seeapoptosis signaling pathway

GTP-binding protein regulators

seeGTP-binding protein regulators

Other

see alsodeficiencies of intracellular signaling peptides and proteins

v t e PDB gallery
1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4 1as0: GTP-GAMMA-S BOUND G42V GIA1 1as2: GDP+PI BOUND G42V GIA1 1as3: GDP BOUND G42V GIA1 1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT 1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM 1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE 1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS 1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS 1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND 1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS 1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS 1git: STRUCTURE OF GTP-BINDING PROTEIN 1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND 1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14 1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP 1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp. 1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange 2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit 2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1 2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity 2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3 2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1 2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

PDB gallery

1agr: COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
1as0: GTP-GAMMA-S BOUND G42V GIA1
1as2: GDP+PI BOUND G42V GIA1
1as3: GDP BOUND G42V GIA1
1bh2: A326S MUTANT OF AN INHIBITORY ALPHA SUBUNIT
1bof: GI-ALPHA-1 BOUND TO GDP AND MAGNESIUM
1cip: GI-ALPHA-1 SUBUNIT OF GUANINE NUCLEOTIDE-BINDING PROTEIN COMPLEXED WITH A GTP ANALOGUE
1gdd: TERTIARY AND QUATERNARY STRUCTURAL CHANGES IN GIA1 INDUCED BY GTP HYDROLYSIS
1gfi: STRUCTURES OF ACTIVE CONFORMATIONS OF GI ALPHA 1 AND THE MECHANISM OF GTP HYDROLYSIS
1gg2: G PROTEIN HETEROTRIMER MUTANT GI_ALPHA_1(G203A) BETA_1 GAMMA_2 WITH GDP BOUND
1gia: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
1gil: STRUCTURE OF ACTIVE CONFORMATIONS OF GIA1 AND THE MECHANISM OF GTP HYDROLYSIS
1git: STRUCTURE OF GTP-BINDING PROTEIN
1gp2: G PROTEIN HETEROTRIMER GI_ALPHA_1 BETA_1 GAMMA_2 WITH GDP BOUND
1kjy: Crystal Structure of Human G[alpha]i1 Bound to the GoLoco Motif of RGS14
1svk: Structure of the K180P mutant of Gi alpha subunit bound to AlF4 and GDP
1svs: Structure of the K180P mutant of Gi alpha subunit bound to GppNHp.
1y3a: Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
2g83: Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
2gtp: Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
2hlb: A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity
2ihb: Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3
2ik8: Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

Hydrolases:acid anhydride hydrolases (EC 3.6)

3.6.1

3.6.2

3.6.3-4:ATPase

3.6.3

Cu++ (3.6.3.4)	Menkes/ATP7A Wilson/ATP7B
Ca+ (3.6.3.8)	SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2
Na+/K+ (3.6.3.9)	ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4
H+/K+ (3.6.3.10)	ATP4A
OtherP-type ATPase	ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3

3.6.4

3.6.5:GTPase

3.6.5.1:Heterotrimeric G protein	G_αs G_olf G_αi GNAI1 GNAI2 GNAI3 Transducin GNAT1 GNAT2 Gustducin GNAT3 G_αq/11 GNAQ GNA11 G_α12/13 GNA12 GNA13
3.6.5.2:Small GTPase >Ras superfamily	Rho family of GTPases:Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 2 3 RhoG RhoBTB 1 2 RhoH Rho A B C Rnd 1 2 3 RhoDF RhoF RhoD other:Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK
3.6.5.3:Protein-synthesizing GTPase	Prokaryotic IF-2 EF-Tu EF-G Eukaryotic
3.6.5.5-6:Polymerization motors	dynamin superfamily Dynamin Guanylate-binding protein Mitofusin-1 MX1 andMX2 OPA1 Tubulin

Retrieved from "https://en.wikipedia.org/w/index.php?title=GNAI1&oldid=1170984449"

Category:

Genes on human chromosome 7

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Interactive pathway map

Interactions

References

Further reading