Protein-coding gene in the species Homo sapiens
Guanine nucleotide-binding protein subunit alpha-13 is aprotein that in humans is encoded by theGNA13 gene .[ 5] [ 6]
Interactions and functions [ edit ] The GNA13 gene encodes the G13 G protein alpha subunit . Together withGNA12 , these two proteins comprise one of the four classes ofheterotrimeric G protein alpha subunits.[ 7] hormone andneurotransmitter signals detected by cell surfaceG protein-coupled receptors tointracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound toGTP but inactive and associated with theG beta-gamma complex when bound toGDP .[ 8] [ 9]
Active GTP-bound G12 alpha subunitinteracts with and activatesARHGEF1 ,[ 10] [ 11] [ 12] ARHGEF11 ,[ 13] [ 14] ARHGEF12 .[ 15] [ 16] guanine nucleotide exchange factors for theRho small GTPases to regulate theactin cytoskeleton .[ 17]
GNA13 has been shown tointeract withAKAP3 ,[ 18] RIC8A ,[ 19] [ 20] Radixin .[ 21]
Clinical significance [ edit ] Recurrent mutations in this gene have been associated to cases ofdiffuse large B-cell lymphoma .[ 22] [ 23]
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This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
