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GLRX3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
GLRX3
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2DIY,2WZ9,2YAN,3ZYW

Identifiers
AliasesGLRX3, GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, glutaredoxin 3
External IDsOMIM:612754;MGI:1353653;HomoloGene:4769;GeneCards:GLRX3;OMA:GLRX3 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for GLRX3
Genomic location for GLRX3
Band10q26.3Start130,136,391bp[1]
End130,184,521bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for GLRX3
Genomic location for GLRX3
Band7|7 F4Start137,039,343bp[2]
End137,070,323bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • islet of Langerhans

  • right testis

  • left testis

  • mucosa of esophagus

  • right adrenal gland

  • right adrenal cortex

  • left adrenal gland

  • left adrenal cortex

  • body of pancreas
Top expressed in
  • spermatid

  • Ileal epithelium

  • spermatocyte

  • choroid plexus of fourth ventricle

  • lactiferous gland

  • yolk sac

  • cardiac muscle tissue of left ventricle

  • ventricular zone

  • embryo

  • genital tubercle
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10539

30926

Ensembl

ENSG00000108010

ENSMUSG00000031068

UniProt

O76003

Q9CQM9

RefSeq (mRNA)

NM_001199868
NM_006541
NM_001321980

NM_023140
NM_001348093

RefSeq (protein)

NP_001186797
NP_001308909
NP_006532

NP_075629
NP_001335022

Location (UCSC)Chr 10: 130.14 – 130.18 MbChr 7: 137.04 – 137.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutaredoxin-3 is aprotein that in humans is encoded by theGLRX3gene.[5][6][7]

Interactions

[edit]

GLRX3 has been shown tointeract withPRKCQ.[5]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000108010 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000031068 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abWitte S, Villalba M, Bi K, Liu Y, Isakov N, Altman A (Feb 2000)."Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain".J Biol Chem.275 (3):1902–9.doi:10.1074/jbc.275.3.1902.PMID 10636891.
  6. ^Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (Jan 2001)."Characterization of 16 novel human genes showing high similarity to yeast sequences".Yeast.18 (1):69–80.doi:10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H.PMID 11124703.S2CID 21397515.
  7. ^"Entrez Gene: TXNL2 thioredoxin-like 2".

Further reading

[edit]

External links

[edit]
  • Overview of all the structural information available in thePDB forUniProt:O76003 (Human Glutaredoxin-3 (GLRX3)) at thePDBe-KB.


PDB gallery
  • 1wik: Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein
    1wik: Solution Structure of the PICOT homology 2 domain of the mouse PKC-interacting cousin of thioredoxin protein
  • 2diy: The solution structure of the thioredoxin domain of human Thioredoxin-like protein 2
    2diy: The solution structure of the thioredoxin domain of human Thioredoxin-like protein 2
Otheroxidoreductases (EC 1.15–1.21)
1.15: Acting onsuperoxide as acceptor
1.16: Oxidizingmetal ions
1.17: Acting on CH or CH2 groups
1.18: Acting oniron–sulfur proteins as donors
1.19: Acting on reducedflavodoxin as donor
1.20: Acting onphosphorus orarsenic in donors
1.21: Acting on X-H and Y-H to form an X-Y bond


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