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GABRR3

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

GABRR3

Identifiers

Aliases

GABRR3, gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene), gamma-aminobutyric acid type A receptor subunit rho3

External IDs

MGI:3588203;HomoloGene:26716;GeneCards:GABRR3;OMA:GABRR3 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q11.2	Start	97,985,102bp^[1]
Band	3q11.2	End	98,035,315bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C1.3	Start	59,227,695bp^[2]
Band	16\|16 C1.3	End	59,284,867bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

gonad

islet of Langerhans

liver

right lobe of liver

spleen

nucleus accumbens

Top expressed in

primary oocyte

secondary oocyte

neural layer of retina

zygote

embryo

vasculature

vasculature of organ

spinal cord

temporal lobe

amygdala

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	chloride channel activity GABA-A receptor activity extracellular ligand-gated ion channel activity ion channel activity transmembrane signaling receptor activity protein domain specific binding
Cellular component	membrane integral component of membrane cell junction GABA-A receptor complex plasma membrane postsynaptic membrane synapse chloride channel complex cellular component integral component of plasma membrane neuron projection
Biological process	gamma-aminobutyric acid signaling pathway chloride transport chloride transmembrane transport ion transport chemical synaptic transmission ion transmembrane transport signal transduction regulation of membrane potential nervous system process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


200959


328699

Ensembl


ENSG00000183185


ENSMUSG00000074991

UniProt


A8MPY1


B2RXA8

RefSeq (mRNA)


NM_001105580


NM_001081190

RefSeq (protein)


NP_001099050


NP_001074659

Location (UCSC)

Chr 3: 97.99 – 98.04 Mb

Chr 16: 59.23 – 59.28 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Gamma-aminobutyric acid receptor subunit rho-3 is aprotein that in humans is encoded by theGABRR3gene.^[5] Theprotein encoded by this gene is a subunit of theGABA_A-ρ receptor.

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000183185 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000074991 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bailey ME, Albrecht BE, Johnson KJ, Darlison MG (October 1999). "Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3".Biochim. Biophys. Acta.1447 (2–3):307–312.doi:10.1016/S0167-4781(99)00167-0.PMID 10542332.

External links

[edit]

GABRR3+protein,+human at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

Ion channel,cell surface receptor:ligand-gated ion channels

Cys-loop receptors

5-HT/serotonin	5-HT₃ A B C D E
GABA	GABA_A α₁ α₂ α₃ α₄ α₅ α₆ β₁ β₂ β₃ γ₁ γ₂ γ₃ δ ε π θ GABA_A-ρ ρ₁ ρ₂ ρ₃
Glycine	α₁ α₂ α₃ α₄ β
Nicotinic acetylcholine	monomers:α1 α2 α3 α4 α5 α6 α7 α9 α10 β1 β2 β3 β4 δ ε pentamers:(α3)₂(β4)₃ (α4)₂(β2)₃ (α7)₅ (α1)₂(β4)₃ - Ganglion type (α1)₂β1δε - Muscle type
Zinc	Zinc-activated