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Fursultiamine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fursultiamine
Skeletal formula of fursultiamine
Ball-and-stick model of the fursultiamine molecule
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Oral
ATC code
  • None
Legal status
Legal status
Identifiers
  • N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-{(1E)-4-hydroxy-1-methyl-2-[(tetrahydrofuran-2-ylmethyl)disulfanyl]but-1-en-1-yl}formamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.011.234Edit this at Wikidata
Chemical and physical data
FormulaC17H26N4O3S2
Molar mass398.54 g·mol−1
3D model (JSmol)
  • O=CN(\C(=C(\SSCC1OCCC1)CCO)C)Cc2cnc(nc2N)C

Fursultiamine (INN; chemical namethiamine tetrahydrofurfuryl disulfide orTTFD; brand namesAdventan,Alinamin-F,Benlipoid,Bevitol Lipophil,Judolor,Lipothiamine) is a medication and vitamin used to treatthiamine deficiency. Chemically, it is adisulfidederivative of thiamine and is similar in structure toallithiamine.[1]

It was synthesized inJapan in the 1960s fromallithiamine for the purpose of developing forms of thiamine with improvedlipophilicity for treatingvitamin B1 deficiency (i.e.,beriberi),[1] It was subsequently commercialized not only in Japan but also inSpain,Austria,Germany, and theUnited States.[2]

See also

[edit]

References

[edit]
  1. ^abLonsdale D (September 2004)."Thiamine tetrahydrofurfuryl disulfide: a little known therapeutic agent".Medical Science Monitor.10 (9): RA199–203.PMID 15328496.
  2. ^Swiss Pharmaceutical Society (2000).Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932.ISBN 3-88763-075-0.

Further reading

[edit]
Fat
soluble
A
D
E
K (B02B)
Water
soluble
B
C
Combinations
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