Highmore was educated at The Brookland Junior and Infant school inHampstead Garden Suburb near Golders Green in the London Borough of Barnet until the age of 11 and gained a scholarship to attendHighgate School, an independent school in Highgate, London.
In 2008, Highmore receivedA* grades in English language and English literature, maths, Spanish, French, Latin, geography, biology, chemistry, and physics in hisGCSE exams.[5] In 2010, Highmore once again achieved A* grades in maths, further maths, French, and Spanish in hisA-level exams.[6]
From 2010 to 2014, Highmore attendedEmmanuel College, Cambridge, where he earned adouble first in Spanish and Arabic.[7] He also enrolled at theLondon School of Economics to study finance at summer school during the summer break at Cambridge in 2011.[8] Highmore worked atGulf Bank in Kuwait as an intern in 2012 and at a law firm inMadrid during his year abroad while filming the first two seasons ofBates Motel, which made him briefly consider becoming a lawyer after graduation.[9]
Highmore began his acting career with small roles on television at the age of 7. He made his film debut inCoky Giedroyc's comedyWomen Talking Dirty (1999), playing the son of a woman who has recently become estranged from her commitment-phobic French lover.[1] In 2001, Highmore played a youngKing Arthur in theTNT miniseriesThe Mists of Avalon, a take on the Arthurian legends that depicted the women ofCamelot as the real power behind the throne.[1]
In 2001, in theBBC miniseriesHappy Birthday Shakespeare, he portrayed a young boy who dreams of moving his family toStratford-upon-Avon.[1] Highmore has acted alongside members of his family in two separate films: he and his brother played siblings inWomen Talking Dirty, and he and his father played a father and son inHallmark Entertainment's television filmJack and the Beanstalk: The Real Story (2001).[10]
He next appeared as a young Max Skinner inRidley Scott's comedy-drama filmA Good Year, which was released in the UK on 27 October 2006. Also in 2006, he began portraying protagonist Arthur Montgomery in the live-action/animated fantasy adventure filmArthur and the Invisibles, released on 13 December 2006. Two sequels followed:Arthur and the Revenge of Maltazard (2009) andArthur 3: The War of the Two Worlds (2010).[12] For the third film and the trilogy'saccompanying video game, Highmore provided voice acting.[13] In 2007, he lent his voice to the adventure fantasy filmThe Golden Compass (2007) and itsvideo game of the same name. He then portrayed the title character in the drama filmAugust Rush (2007). The story follows a musical prodigy as he searches for his birth parents. This film received a wide release on 21 November 2007.
Highmore has been cast as the voice of the Duke of Cheshire in the animated film adaptation ofThe Canterville Ghost.[35] He is to play the title character,Baby Face Nelson, in the A&E drama pilotBaby Face, which he co-wrote and will executive produce with Kerry Ehrin.[36] Highmore will also serve as an executive producer on Ehrin's drama pilotLong Distance for NBC.[37]
In August 2018, Highmore formed his Sony-aligned production company, Alfresco Pictures, which aims to develop scripted series for broadcast, cable, streaming services, and international co-productions projects "that have a broader point or message behind them, that try and spark conversations that aren't being had or give a microphone to voices and experiences that haven't been heard from before.". "I hope 'Alfresco', aside from being a play on my real name, Alfred, speaks more widely to a sense of refreshing, communal openness that is reflective of the stories we gravitate towards at the company," he said. "In wanting to set up 'Alfresco', it came from a natural desire to be involved in a wider way in the industry ... I always had that natural curiosity to do other things. And that, I guess, shifted into not only wanting to develop my own ideas and projects that I was writing or directing or acting in, but also becoming a producer in a wider sense and helping other people tell their stories."[38]
In August 2019, it was reported that Highmore will co-write and serve as an executive producer forHomesick, a dark comedy in development at the WarnerMedia-owned cable net, which will explore mental health, body image, toxic masculinity and what it means to defy "normal" gender expectations.[39]
Highmore lives in London and avoids social media.[40] While onBates Motel, Highmore developed a close friendship with co-starVera Farmiga and becamegodfather to her son.[41]
Apart from his native English, Highmore is fluent in French and Spanish, and semi-fluent in Arabic.[42][43]
In a September 2021 interview onJimmy Kimmel Live!, Highmore revealed that he had recently married.[44]