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Fourphit

From Wikipedia, the free encyclopedia
Pharmaceutical compound
Fourphit
Clinical data
Other names4-Isothiocyanato-PCP
Drug classIrreversibledopamine transporter blocker;ReversibleNMDA receptor antagonist;Psychostimulantantagonist
Identifiers
  • 4-isothiocyanato-1-(1-phenylcyclohexyl)piperidine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H24N2S
Molar mass300.46 g·mol−1
3D model (JSmol)
  • C1CCC(CC1)(C2=CC=CC=C2)N3CCC(CC3)N=C=S
  • InChI=1S/C18H24N2S/c21-15-19-17-9-13-20(14-10-17)18(11-5-2-6-12-18)16-7-3-1-4-8-16/h1,3-4,7-8,17H,2,5-6,9-14H2
  • Key:QAHYIAVTWZVTMY-UHFFFAOYSA-N

Fourphit, also known as4-isothiocyanato-PCP, is anirreversibledopamine transporter (DAT)blocker and a reversibleNMDA receptor antagonist.[1][2] It blocks the binding ofmethylphenidate to the DATin vitro,[1] though apparently notin vivo.[2] In any case, the drug reduces thestimulant-like effects ofcocaine in animals,[2] whilst producing mostly negligible behavioral effects itself.[2] Fourphit is anacylatingderivative ofphencyclidine (PCP) and apositional isomer ofmetaphit (3-isothiocyanato-PCP).[1]

See also

[edit]

References

[edit]
  1. ^abcSchweri MM, Thurkauf A, Mattson MV, Rice KC (June 1992). "Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter".J Pharmacol Exp Ther.261 (3):936–942.PMID 1602399.
  2. ^abcdSchweri MM, de Costa BR, Rice KC (July 1998). "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats".Pharmacol Biochem Behav.60 (3):615–623.doi:10.1016/s0091-3057(98)00040-9.PMID 9678644.
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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