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Foundation Medicine

From Wikipedia, the free encyclopedia
American genomics company
Foundation Medicine, Inc.
Company typeSubsidiary
Nasdaq: FMI
Headquarters,
United States
Key people
Daniel Malarek (CEO)
ProductsFoundationOne CDx FoundationOne Liquid FoundationOne Heme Foundation Insights FoundationSmartTrials
RevenueIncrease $152.9 million (2017)[1]
ParentRoche
Websitefoundationmedicine.com

Foundation Medicine, Inc. is an American company based inCambridge, Massachusetts, which develops, manufactures, and sells genomic profilingassays based onnext-generation sequencing technology forsolid tumors,hematologic malignancies, andsarcomas.[2]

History

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Foundation Medicine was founded in Cambridge, Massachusetts.[3] The company was conceived afterBroad Institute researchersLevi Garraway andMatthew Meyerson published a 2007 paper detailing a method for large-panel testing of 238 DNAmutations.[4]

Foundation Medicine launched in 2010 with a $25 millionSeries A financing led byThird Rock Ventures.[5] The company released its first commercial assay, or test, called FoundationOne in 2012.[6] The company also began partnering with pharmaceutical companies to analyze patient samples.[4] The first such program was piloted withNovartis in 2011,[5] and by 2018, the company had more than 30 partnerships.[7]

Foundation Medicine launched its second test, ahematologicalbiomarker assay called FoundationOneHeme, in 2013.[8] The company held its initial public offering in August 2013.[9] The following year,Priority Health in Michigan became the first healthcare plan in the United States to cover the company's tests.[10]

In 2016, using FoundationCore data, Foundation Medicine released anonymized records detailing genomic data on cancers from 18,000 adult patients to theNational Cancer Institute's (NCI) Genomic Data Commons (GDC) portal.[11]

In 2018, Roche acquired Foundation Medicine (via acquisition of the remaining 42.5% of Foundation Medicine for $2.4 billion), and currently operates it as asubsidiary.[12][13]

Guardant Health sued Foundation Medicine overpatents in 2019–2020.[14][15] In 2021, Guardant Health licensedintellectual property to Foundation Medicine for $25 million in asettlement.[16]

Products

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Foundation Medicine's products include genomic tests for solid tumors and blood-based cancers and sarcomas,[17] as well as data services.

  • FoundationOne CDx is a CGP test providing information for five tumor types: ovarian, lung, breast, colorectal, and melanoma.[18]
  • FoundationOne Liquid
  • FoundationOne Heme[8]
  • The company's FoundationCore database contains more than 300,000 genomic profiles sourced from the results of the company's assays as well as information on over 150 subtypes of cancer.[19]

References

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  1. ^"Foundation Medicine Announces 2017 Fourth Quarter and Year-End Results, Recent Highlights and 2018 Outlook | Foundation Medicine".
  2. ^Staff (15 January 2015)."Cambridge startup soars on Roche stake". Business.The Boston Globe.
  3. ^Allan Maurer (September 28, 2017)."Foundation Medicine building RTP lab into key hub".WRAL TechWire. Retrieved18 January 2018.Foundation, founded in Cambridge, Mass., in 2010
  4. ^abAdrienne Burke (February 21, 2012)."Foundation Medicine: Personalizing Cancer Drugs".MIT Technology Review. Retrieved18 January 2018.
  5. ^abJulia Karow (April 13, 2011)."Foundation Medicine Developing Targeted Sequencing Test for 'Clinically Actionable' Cancer Genes".Genome Web. Retrieved18 January 2018.
  6. ^Ron Winslow (January 12, 2015)."Roche Holding to Pay $1.03 Billion for Diagnostics-Firm Stake".The Wall Street Journal. Retrieved18 January 2018.
  7. ^Julia Karrow (8 March 2018)."Foundation Medicine to Grow Clinical Testing, Pharma Business in 2018".GenomeWeb. Retrieved18 June 2018.
  8. ^abJulia Karow (December 11, 2013)."LabCorp Steps into NGS-based Oncology Market as Foundation Medicine Adds Hematologic Cancer Test".Genome Web. Retrieved18 January 2018.
  9. ^Don Seiffert (December 4, 2014)."Foundation Medicine still growing a year after launching blood-cancer test".Boston Business Journal. Retrieved18 January 2018.
  10. ^Don Seiffert (November 20, 2014)."Foundation Medicine's shares gain on flurry of good news ahead of earnings call".Boston Business Journal. Retrieved18 January 2018.
  11. ^Constance Gustke (July 6, 2017)."Joe Biden's moonshot to crack the code on cancer, one of the biggest killers in America".CNBC. Retrieved18 January 2018.
  12. ^Shields M, Hirschler B (19 June 2018)."Roche pays $2.4 billion for rest of cancer expert Foundation Medicine".Reuters. Archived fromthe original on June 19, 2018.
  13. ^"Roche and Foundation Medicine reach definitive merger agreement to accelerate broad availability of comprehensive genomic profiling in oncology".
  14. ^Han, Andrew P. (January 6, 2020)."Guardant Health CEO Deleted Email Evidence After Lawsuit Deposition".GenomeWeb. RetrievedSeptember 6, 2022.
  15. ^Leuty, Ron (November 24, 2020)."Showdown over 'liquid biopsy' patents lands two cancer test players in court again".San Francisco Business Times. RetrievedSeptember 1, 2022.
  16. ^"Guardant Health to License IP to Foundation Medicine for $25M, Royalties Under Settlement Agreement".GenomeWeb. May 21, 2021. RetrievedSeptember 6, 2022.
  17. ^Dr. Hung Tran (23 April 2018)."Foundation Medicine: To Profit From The Increasing Trend Of Personalized Treatment".Seeking Alpha. Retrieved13 September 2018.
  18. ^Jonathan Saltzman (June 20, 2018)."Roche will pay $2.4 billion to complete its takeover of Foundation Medicine".The Boston Globe. Archived fromthe original on 14 September 2018. Retrieved13 September 2018.
  19. ^Alex Philippidis (January 16, 2018)."Pfizer Joins Foundation Medicine to Develop Cancer CDx".GEN. Retrieved18 January 2018.

External links

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