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| Trade names | Coreminal(JP) |
| Other names | 13-chloro- 2-(2-fluorophenyl)- 9-(2-hydroxyethyl)- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca-1(10),11,13- trien- 8-one |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Eliminationhalf-life | 3.5 hours (parent compound); 47-100 hours (major metabolite) |
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| Chemical and physical data | |
| Formula | C19H18ClFN2O3 |
| Molar mass | 376.81 g·mol−1 |
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Flutazolam[1] (Coreminal, MS-4101) is a drug which is abenzodiazepine derivative. It was invented in Japan, and this is the main country in which it has been used medically. It hassedative,muscle relaxant,anticonvulsant, andanxiolytic effects similar to those produced by other benzodiazepine derivatives, and though it is around the same potency asdiazepam, it produces a more marked sedation and impaired coordination. It is indicated for the treatment ofinsomnia.[2] Its major active metabolite is n-desalkylflurazepam, also known as norflurazepam, which is also a principal metabolite offlurazepam (trade name Dalmane).[3] While flutazolam has a very short half-life of only 3.5 hours, n-desalkylflurazepam has a long half-life of between 47–100 hours.[4]
Flutazolam is closely related in structure to another benzodiazepine,haloxazolam.[5][6]
