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Fluorometholone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fluorometholone
Clinical data
Other names(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.comMonograph
MedlinePlusa682660
ATC code
Legal status
Legal status
Identifiers
  • (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.006.402Edit this at Wikidata
Chemical and physical data
FormulaC22H29FO4
Molar mass376.468 g·mol−1
3D model (JSmol)
  • O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
  • InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 checkY
  • Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fluorometholone (INN,BAN,JAN) (brand namesEfflumidex,Flucon,FML Forte,FML, others), also known as6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is asyntheticglucocorticoid which is used in the treatment ofinflammatoryeye diseases.[2][3][4] The C17αacetateester,fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.[2][3][4]

References

[edit]
  1. ^"Product monograph brand safety updates".Health Canada. February 2024. Retrieved24 March 2024.
  2. ^abElks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 566–.ISBN 978-1-4757-2085-3.
  3. ^abIndex Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 458–.ISBN 978-3-88763-075-1.
  4. ^abMorton IK, Hall JM (6 December 2012).Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 123–.ISBN 978-94-011-4439-1.
Glucocorticoids
Natural
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Antihemorrhoidals for topical use
corticosteroids
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GRTooltip Glucocorticoid receptor
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
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PRTooltip Progesterone receptor
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(SPRMsTooltip Selective progesterone receptor modulators)
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mPRTooltip Membrane progesterone receptor
(PAQRTooltip Progestin and adipoQ receptor)
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CARTooltip Constitutive androstane receptor
PXRTooltip Pregnane X receptor


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