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Fluocinonide

From Wikipedia, the free encyclopedia
Chemical compound
"Vanos" redirects here; not to be confused withVANOS orVanossGaming.

Pharmaceutical compound
Fluocinonide
Clinical data
Trade namesFluonex, Lidex, others[1]
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601054
Routes of
administration
Topical
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Identifiers
  • 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.005.998Edit this at Wikidata
Chemical and physical data
FormulaC26H32F2O7
Molar mass494.532 g·mol−1
3D model (JSmol)
  • O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C
  • InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 checkY
  • Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N checkY
  (verify)

Fluocinonide is a potentglucocorticoid usedtopically as ananti-inflammatory agent for the treatment ofskin disorders such aseczema andseborrhoeic dermatitis.[2] It relievesitching, redness,dryness, crusting, scaling,inflammation, and discomfort.[2]

A common potential adverse effect is skin atrophy (thinning of the skin).[3]

In 2022, it was the 266th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[4][5]

Veterinary uses

[edit]

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[6] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[7]

References

[edit]
  1. ^"Fluocinonide Topical".MedlinePlus Drug Information. U.S. National Library of Medicine.
  2. ^ab"Fluocinonide Topical: MedlinePlus Drug Information".medlineplus.gov. Retrieved16 November 2022.
  3. ^Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids".The British Journal of Dermatology.100 (2):193–206.doi:10.1111/j.1365-2133.1979.tb05561.x.PMID 154921.S2CID 30656827.
  4. ^"The Top 300 of 2022".ClinCalc.Archived from the original on 30 August 2024. Retrieved30 August 2024.
  5. ^"Fluocinonide Drug Usage Statistics, United States, 2013 - 2022".ClinCalc. Retrieved30 August 2024.
  6. ^Dog Allergies.Squidoo (Report).
  7. ^Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs".Journal of the American Veterinary Medical Association.191 (6):685–688.doi:10.2460/javma.1987.191.06.685.PMID 2824410.
Glucocorticoids
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Antihemorrhoidals for topical use
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heparins orheparinoids for topical use
sclerosing agents for local injection
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GRTooltip Glucocorticoid receptor
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
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