Movatterモバイル変換

[0]ホーム
URL:

Jump to content
WikipediaThe Free Encyclopedia
Search

Fluacizine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fluacizine
Skeletal formula of fluacizine
Space-filling model of the fluacizine molecule
Clinical data
Trade namesPhtorazisin
Other namesFluoracizine; Fluoracyzine; Fluoracisine; Ftoracizin; Ftoracizine; Phthoracizin[1][2]
Routes of
administration		Oral,intramuscular injection
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 3-Diethylamino-1-[2-(trifluoromethyl)phenothiazin-10-yl]-propan-1-one
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC20H21F3N2OS
Molar mass394.46 g·mol−1
3D model (JSmol)
  • FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)C(=O)CCN(CC)CC
  • InChI=1S/C20H21F3N2OS/c1-3-24(4-2)12-11-19(26)25-15-7-5-6-8-17(15)27-18-10-9-14(13-16(18)25)20(21,22)23/h5-10,13H,3-4,11-12H2,1-2H3 checkY
  • Key:VHEOUJNDDFHPGJ-UHFFFAOYSA-N checkY
  (verify)

Fluacizine, sold under the brand namePhtorazisin, is atricyclic antidepressant (TCA) of thephenothiazine group which is or was marketed inRussia.[1][2][3] Unlike other phenothiazines, fluacizine is not anantipsychotic, and can actually reversecatalepsy andextrapyramidal symptoms induced byantidopaminergic agents like antipsychotics,reserpine, andtetrabenazine as well as potentiateamphetamine-inducedstereotypy.[3] It is known to act as anorepinephrine reuptake inhibitor,antihistamine, andanticholinergic.[4][5][6][7][3] The drug was developed in the 1960s and was marketed in the 1970s.[1][4] It is thetrifluoromethylanalogue ofchloracizine.[7]

See also

[edit]

References

[edit]
  1. ^abcJ. Elks (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 555–.ISBN 978-1-4757-2085-3.
  2. ^abO'Neil, Maryadele J. (2001).The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Rahway, NJ: Merck Research Laboratories.ISBN 0-911910-13-1.
  3. ^abcV. V. Zakusov (22 October 2013).Pharmacology of Central Synapses. Elsevier. pp. 190–.ISBN 978-1-4831-4673-7.
  4. ^abArefolov VA, Panasyuk LV, Raevskii KS, Kostyukov VI (1974). "Effect of fluacizine on the uptake of exogenous noradrenalin by the isolated rat vas deferens".Bull. Exp. Biol. Med.77 (3):295–7.doi:10.1007/BF00802484.PMID 4153328.S2CID 13188296.
  5. ^Arefolov VA, Panasyuk LV (1974). "Effect of fluacizine on the uptake of exogenous noradrenalin".Bull. Exp. Biol. Med.77 (5):520–3.doi:10.1007/BF00797411.PMID 4441683.S2CID 27205700.
  6. ^Arefolov VA, Panasiuk LV, Firsov VK (1975). "[Neuromediator content in the synaptic vesicles of rat adrenergic nerves in some pharmacological actions]".Farmakol Toksikol (in Russian).38 (3):285–9.PMID 6305.
  7. ^abAnnual Reports in Medicinal Chemistry. Academic Press. 27 October 1972. pp. 19–.ISBN 978-0-08-058351-8.
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)
Classes
Antidepressants
(Tricyclic antidepressants(TCAs))
Antihistamines
Antipsychotics
Anticonvulsants
Anticholinergics
Others


Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Fluacizine&oldid=1250025461"
Categories:
Hidden categories:
[8]ページ先頭
©2009-2025 Movatter.jp