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Fletikumab

From Wikipedia, the free encyclopedia
Monoclonal antibody
Pharmaceutical compound
Fletikumab
Monoclonal antibody
Type?
TargetIL20
Clinical data
Other namesNNC0109-0012
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC6494H10000N1728O2050S44
Molar mass146492.12 g·mol−1

Fletikumab (NNC0109-0012) (INN[1]) is a monoclonal antibody designed for the treatment ofrheumatoid arthritis[2] that targetsIL-20.[3]

This drug was being developed byNovo Nordisk A/S until Novo ceased work in inflammation.

References

[edit]
  1. ^World Health Organization (2013)."International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 110"(PDF).WHO Drug Information.27 (4).
  2. ^Statement On A Nonproprietary Name Adopted By The USAN Council - Fletikumab,American Medical Association.
  3. ^Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, Taylor PC, Senolt L, Deleuran B (2018)."The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis".Frontiers in Immunology.9: 2226.doi:10.3389/fimmu.2018.02226.PMC 6167463.PMID 30319661.
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others


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