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Firocoxib

From Wikipedia, the free encyclopedia
COX-2 selective NSAID veterinary drug

Pharmaceutical compound
Firocoxib
Firocoxib molecule
Clinical data
Trade namesEquioxx, Previcox
AHFS/Drugs.com
License data
Routes of
administration
By mouth
ATCvet code
Legal status
Legal status
Identifiers
  • 3-(Cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC17H20O5S
Molar mass336.40 g·mol−1
3D model (JSmol)
  • O=C2OC(C(=C2\OCC1CC1)\c3ccc(cc3)S(=O)(=O)C)(C)C
  • InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3 checkY
  • Key:FULAPETWGIGNMT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Firocoxib, sold under the brand namesEquioxx andPrevicox among others, is anonsteroidal anti-inflammatory drug of theCOX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox).[2][4][9] Firocoxib was the first COX-2 inhibitor approved by the U.S.Food and Drug Administration for horses.[10] Firocoxib is not intended or approved for use in human medicine.[2][4][5][6][11]

Firocoxib, manufactured by Merial, was approved for veterinary use in the United States for dogs in July 2004,[12] and for horses in July 2007, as an oral paste (Equioxx) and July 2016, as tablets.[13][14]

Firocoxib is also available as ageneric medication for horses[14] and for dogs.[12]

References

[edit]
  1. ^"Product information".Health Canada. 22 October 2009. Retrieved9 February 2024.
  2. ^abc"Equioxx- firocoxib tablet, chewable".DailyMed. 14 July 2020.Archived from the original on 3 August 2022. Retrieved2 August 2022.
  3. ^"Equioxx- firocoxib paste".DailyMed. 24 February 2022.Archived from the original on 3 August 2022. Retrieved2 August 2022.
  4. ^abc"Previcox- firocoxib tablet, chewable".DailyMed. 23 July 2020.Archived from the original on 3 August 2022. Retrieved2 August 2022.
  5. ^ab"Equioxx EPAR".European Medicines Agency (EMA). 30 June 2008.Archived from the original on 25 April 2022. Retrieved2 August 2022.
  6. ^ab"Previcox EPAR".European Medicines Agency (EMA). 16 March 2007.Archived from the original on 31 July 2021. Retrieved2 August 2022.
  7. ^"Coxatab EPAR".European Medicines Agency (EMA). 17 June 2022. Retrieved9 February 2024.
  8. ^"Previcox PI".Union Register of medicinal products. 15 September 2004. Retrieved26 December 2024.
  9. ^Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P (June 2019). "Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses".Journal of Equine Veterinary Science.77:36–42.doi:10.1016/j.jevs.2019.02.007.PMID 31133314.S2CID 86530623.
  10. ^"New NSAID Equioxx (firocoxib) Approved by USEF".The Horse. 2 July 2007.Archived from the original on 18 May 2011. Retrieved18 April 2008.
  11. ^EquioxxArchived 21 December 2014 at theWayback Machine,European Medicines Agency (EMA)
  12. ^ab"FDA Approves the First Generic Firocoxib Tablets for Dogs".U.S. Food and Drug Administration. 7 June 2022.Archived from the original on 3 August 2022. Retrieved2 August 2022.
  13. ^"Merial launches first firocoxib for horses".DVM 360. 1 July 2007. Retrieved3 October 2023.
  14. ^ab"FDA Approves the First Generic Firocoxib Tablets for Horses".U.S.Food and Drug Administration (FDA). 1 August 2022.Archived from the original on 3 August 2022. Retrieved2 August 2022.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
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(
PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthase
PGFSTooltip Prostaglandin F synthase
PGI2STooltip Prostacyclin synthase
TXASTooltip Thromboxane A synthase
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