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Fenpiverinium

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fenpiverinium
Clinical data
ATC code
Identifiers
  • 1-(4-Amino-4-oxo-3,3-diphenylbutyl)-1-methylpiperidinium
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H29N2O+
Molar mass337.487 g·mol−1
3D model (JSmol)
  • C[N+]1(CCCCC1)CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N
  • InChI=1S/C22H28N2O/c1-24(16-9-4-10-17-24)18-15-22(21(23)25,19-11-5-2-6-12-19)20-13-7-3-8-14-20/h2-3,5-8,11-14H,4,9-10,15-18H2,1H3,(H-,23,25)/p+1
  • Key:QDIYJDPBMZUZEH-UHFFFAOYSA-O
  (verify)

Fenpiverinium is ananticholinergic andantispasmodic compound;[1] it is marketed as acombination drug withpitofenone hydrochloride and eithernimesulide ormetamizole in Eastern Europe and India to treat smooth muscle spasms and pain.[2]

The combination with metamizole was removed from the market in Lithuania for safety reasons in 2000[3] and a boxed warning against use by children and adolescents was added in Serbia in 2005.[4] In 2016 India banned marketing of the combination with nimesulide along with 344 other combination drugs;[5][6] the order was overturned in December and appealed by the Government in January 2017.[7]

References

[edit]
  1. ^"Proposed INNs List 26"(PDF).WHO Chronicle.25 (9). 1971.."Recommended INNs List 12"(PDF).WHO Chronicle.26 (10). 1973.
  2. ^Vardanyan R (2017).Piperidine-Based Drug Discovery. Elsevier.ISBN 9780128134283.
  3. ^Consolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue. WHO. 2005. p. 305. Archived fromthe original on November 8, 2014.
  4. ^Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments, Fourteenth Issue. WHO. 2009. p. 35.[dead link]
  5. ^"Health ministry bans 344 fixed dose combination drugs".The Times of India. March 14, 2016.
  6. ^"Gazette of India D. L.-33004/99. PART II—Section 3—Sub-section (ii)"(PDF). Government of India. March 10, 2016. Archived fromthe original(PDF) on 2018-08-26. Retrieved2017-06-22.
  7. ^"Govt moves SC to enforce ban on 344 Fixed Dose Combination drugs".The Times of India. January 31, 2017.
Drugs for
functional
bowel
disorders
Antimuscarinics
Tertiary
amino group
Quaternary
ammonium

compounds
Phosphodiesterase
inhibitors
Acting on
serotonin receptors
Other
Belladonna
and derivatives
(antimuscarinics)
Propulsives
mAChRsTooltip Muscarinic acetylcholine receptors
Agonists
Antagonists
Precursors
(andprodrugs)


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