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| Clinical data | |
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| Trade names | Nalfon |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a681026 |
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| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Metabolism | Major urinary metabolites are fenoprofen glucuronide and 4′-hydroxyfenoprofen glucuronide. |
| Eliminationhalf-life | 3 hours |
| Excretion | Renal (~90%) |
| Identifiers | |
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| CAS Number | |
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| IUPHAR/BPS | |
| DrugBank |
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| ChemSpider |
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| UNII | |
| KEGG |
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| ChEBI | |
| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.046.213 100.045.231, 100.046.213 |
| Chemical and physical data | |
| Formula | C15H14O3 |
| Molar mass | 242.274 g·mol−1 |
| 3D model (JSmol) | |
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Fenoprofen, sold under the brand nameNalfon among others, is anonsteroidal anti-inflammatory drug (NSAID). Fenoprofen calcium is used for symptomatic relief for rheumatoid arthritis, osteoarthritis, and mild to moderate pain. It has also been used to treat postoperative pain.[2] It is available as ageneric medication.[3][4]
Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase (COX-2 inhibitor) activity and prostaglandin synthesis.
Fenoprofen is chiral drug with one stereogenic center and exists as chiral twins. (S)-enantiomer has the desired pharmacological action where as the (R)-isomer is less active. It is observed that there is stereoselective bioconversion of the (R)- to (S)-fenoprofen. This stereoselective conversion is calledchiral inversion.[5][6]
History of significantly impaired renal function; patients with known hypersensitivity to any component of the product; patients who have experiencedasthma,urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; treatment of perioperative pain in the setting ofcoronary artery bypass graft (CABG) surgery.
In October 2020, the U.S.Food and Drug Administration (FDA) required thedrug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[7][8] They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[7][8]
False elevation in free and total serum T 3 as measured by Amerlex-M kit.[medical citation needed]
This article incorporates text from this source, which is in thepublic domain. This article incorporates text from this source, which is in thepublic domain.| pyrazolones / pyrazolidines | |
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| salicylates | |
| acetic acid derivatives and related substances | |
| oxicams | |
| propionic acid derivatives (profens) |
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| n-arylanthranilic acids (fenamates) | |
| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;†withdrawn drugs;‡veterinary use. | |
