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Fengabine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Fengabine
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • (6Z)-6-[butylamino-(2-chlorophenyl)methylene]-4-chloro-cyclohexa-2,4-dien-1-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC17H17Cl2NO
Molar mass322.23 g·mol−1

Fengabine (SL-79,229) is adrug which was investigated as anantidepressant but was never marketed.[1][2] Itsmechanism of action is unknown, but its antidepressant effects are reversed byGABAA receptorantagonists likebicuculline and it has hence been labeled asGABAergic; however, it does not actuallybind toGABA receptors, nor does it inhibitGABA-T.[1][2] Inclinical trials, fengabine's efficacy was comparable to that of thetricyclic antidepressants, but with a more rapidonset of action and much lessside effects.[3][4][5] Notably, fengabine lacks anysedative effects.[4]

See also

[edit]

References

[edit]
  1. ^abLloyd KG, Zivkovic B, Sanger D, Depoortere H, Bartholini G (April 1987)."Fengabine, a novel antidepressant GABAergic agent. I. Activity in models for antidepressant drugs and psychopharmacological profile".The Journal of Pharmacology and Experimental Therapeutics.241 (1):245–50.PMID 3033203.
  2. ^abScatton B, Lloyd KG, Zivkovic B, et al. (April 1987)."Fengabine, a novel antidepressant GABAergic agent. II. Effect on cerebral noradrenergic, serotonergic and GABAergic transmission in the rat".The Journal of Pharmacology and Experimental Therapeutics.241 (1):251–7.PMID 3033204.
  3. ^Magni G, Garreau M, Orofiamma B, Palminteri R (1989). "Fengabine, a new GABAmimetic agent in the treatment of depressive disorders: an overview of six double-blind studies versus tricyclics".Neuropsychobiology.20 (3):126–31.doi:10.1159/000118485.PMID 2668780.
  4. ^abNielsen NP, Cesana B, Zizolfi S, Ascalone V, Priore P, Morselli PL (November 1990). "Therapeutic effects of fengabine, a new GABAergic agent, in depressed outpatients: a double-blind study versus clomipramine".Acta Psychiatrica Scandinavica.82 (5):366–71.doi:10.1111/j.1600-0447.1990.tb01402.x.PMID 2281807.S2CID 44534975.
  5. ^Fairweather DB, Kerr JS, Hilton S, Hindmarch I (March 1993)."A placebo controlled double-blind evaluation of the pharmacodynamics of fengabine vs amitriptyline following single and multiple doses in elderly volunteers".British Journal of Clinical Pharmacology.35 (3):278–83.doi:10.1111/j.1365-2125.1993.tb05695.x.PMC 1381575.PMID 8471403.
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Miscellaneous
5-HT1ARTooltip 5-HT1A receptoragonists
GABAARTooltip GABAA receptorPAMsTooltip positive allosteric modulators
Hypnotics
Gabapentinoids
(α2δVDCCblockers)
Antidepressants
Antipsychotics
Sympatholytics
(Antiadrenergics)
Others
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