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Feng Zhang

From Wikipedia, the free encyclopedia
Chinese–American biochemist

In thisChinese name, thefamily name is Zhang (张).
The native form of thispersonal name isZhang Feng. This article usesWestern name order when mentioning individuals.
Feng Zhang
张锋
Zhang in 2017
Born (1981-10-22)October 22, 1981 (age 43)
Shijiazhuang, Hebei, China
NationalityAmerican
Education
Known forOptogenetics,CRISPR
Awards
Scientific career
FieldsNeuroscience
Bioengineering
InstitutionsMassachusetts Institute of Technology
Broad Institute
Thesis Circuit-breakers: optical technologies for probing neural signals and systems (2009)
Doctoral advisorKarl Deisseroth
Other academic advisorsPaola Arlotta,George Church
Doctoral studentsSilvana Konermann,Patrick Hsu
Websitezlab.mit.edu

Feng Zhang (Chinese:张锋;pinyin:Zhāng Fēng; born October 22, 1981) is a Chinese-born American biochemist. Zhang currently holds the James and Patricia Poitras Professorship in Neuroscience at theMcGovern Institute for Brain Research and in the Departments of Brain and Cognitive Sciences andBiological Engineering at theMassachusetts Institute of Technology. He also has appointments with theBroad Institute of MIT and Harvard (where he is a core member). He is most well known for his central role in the development ofoptogenetics andCRISPR technologies.

Early life and education

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Zhang was born in China in 1981 and given the name 锋 (which means "point of a spear; edge of a tool; vanguard"). Both of his parents were computer programmers in China. At age 11, he moved toIowa with his mother (his father was not able to join them for several years).[1] He attendedTheodore Roosevelt High School and Central Academy inDes Moines, graduating in 2000. In 1999, he attended theResearch Science Institute at MIT, and in 2000 he won 3rd place in theIntel Science Talent Search. He earned hisB.A. in chemistry and physics in 2004 fromHarvard University, where he worked withXiaowei Zhuang.[2] He then received his PhD in chemical andbiological engineering fromStanford University in 2009 under the guidance ofKarl Deisseroth where he developed the technologies behindoptogenetics withEdward Boyden.[3][4] He served as an independent Junior Fellow in theHarvard Society of Fellows.[5][6]

Research

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Zhang's lab is focused on usingsynthetic biology to develop technologies for genome and epigenome engineering to study neurobiology. He is a leader in the field ofoptogenetics,[7][8] which was named the 2010 "Method of the Year".[9] As a postdoc, he began work on using TAL effectors to control gene transcription.[6]

Based on previous work by the Sylvain Moineau Lab,[10] Zhang began work to harness and optimize the CRISPR system to work in human cells in early 2011.[11] While Zhang's group was optimizing theCas9 system in human cells, the collaborating groups ofEmmanuelle Charpentier andJennifer Doudna described a chimeric RNA design which is capable of facilitating cleavage of DNA using purified Cas9 protein and a synthetic guide. Zhang's group compared their RNA expression approach with a design based on the Doudna / Charpentier chimeric RNA for use in human cells and established features of the guide necessary for Cas9 to function effectively in mammalian cells[12][13] which are dispensable in biochemical assays.[14][15][16] Zhang, Doudna, and other colleagues from Harvard foundedEditas Medicine in September 2013 to develop and commercialize CRISPR-based therapies.[17]

Zhang discoveredCas13 with Harvard colleagueEugene Koonin usingcomputational biology methods. In 2016, Zhang cofoundedArbor Biotechnologies to develop Cas13 for therapeutic use.[18]

His lab has also developed a sensitive diagnostic nucleic acid detection protocol that is based on CRISPR termed SHERLOCK (Specific High sensitivity Enzymatic Reporter UnLOCKing) that is able to detect and distinguish strains of viruses and bacteria present in as low as attomolar (10−18 M) concentration.[19] Zhang cofoundedSherlock Biosciences in 2018 to further develop this diagnostic technology.[20]

Also in 2018, Zhang cofoundedBeam Therapeutics with Editas cofounder and Harvard colleagueDavid R. Liu to further advance Liu's work on base editing andprime editing.[21][22]

Honors

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Zhang is a recipient of theNIH Director's Pioneer Award and a 2012Searle Scholar. He was named one of MIT Technology Reviews'sTR35[23] in 2013. His work on optogenetics and CRISPR has been recognized by a number of awards, including: the 2011Perl-UNC Prize (shared with Boyden and Deisseroth);[24] the 2014Alan T. Waterman Award, theNational Science Foundation's highest honor that annually recognizes an outstanding researcher under the age of 35;[25] the 2014 Gabbay Award (shared withJennifer Doudna andEmmanuelle Charpentier);[26] the 2014 Young Investigator Award from theSociety for Neuroscience (shared withDiana Bautista) as well as the ISTT Young Investigator Award from theInternational Society for Transgenic Technologies.[27][28] Zhang also received a New York Stem Cell Foundation (NYSCF) – Robertson Stem Cell Investigator Award in 2014, and was named the 2016 NYSCF – Robertson Stem Cell Prize Recipient.

In 2015, Zhang became the inaugural recipient ofTsuneko &Reiji Okazaki Award (Nagoya University)[29] and in 2016, he was once again (for the 2nd and 3rd time) sharing honors with Doudna and Charpentier when receiving theGairdner Foundation International Award[30] and theTang Prize.[31]

In 2016, he became a laureate of theAsian Scientist 100 by theAsian Scientist.[32]

In 2017, he received theAlbany Medical Center Prize (jointly with Emmanuelle Charpentier, Jennifer Doudna,Luciano Marraffini, andFrancisco Mojica)[33] and theLemelson-MIT Prize.[34]

In 2018, Zhang was elected as a Fellow of theAmerican Academy of Arts and Sciences,[35] and a member of theNational Academy of Sciences,[36]National Academy of Medicine.[37]

In 2019, he received theHarvey Prize of the Technion/Israel for the year 2018 (jointly with Emmanuelle Charpentier and Jennifer Doudna).[38] In the same year, Zhang received the Golden Plate Award of theAmerican Academy of Achievement.[39]

Zhang's research on CRISPR-Cas9 gene editing, while significant, was not recognized by the Nobel Prize committee in 2020, which instead awarded the prize to Emmanuelle Charpentier and Jennifer Doudna for their groundbreaking work on the subject.[40]

In 2021, he received theRichard Lounsbery Award.[41]

In 2025, Zhang and Doudna were both recipients of theNational Medal of Technology and Innovation.[42]

References

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  1. ^Begley, Sharon (November 6, 2015)."Meet one of the world's most groundbreaking scientists. He's 34".Stat. RetrievedJanuary 27, 2017.
  2. ^"Zhuang Research Lab".Harvard University. RetrievedJanuary 27, 2017.
  3. ^Boyden, Edward S; Zhang, Feng; Bamberg, Ernst; Nagel, Georg; Deisseroth, Karl (August 14, 2005). "Millisecond-timescale, genetically targeted optical control of neural activity".Nature Neuroscience.8 (9):1263–1268.doi:10.1038/nn1525.PMID 16116447.S2CID 6809511.
  4. ^Zhang, Feng; Wang, Li-Ping; Brauner, Martin; Liewald, Jana F.; Kay, Kenneth; Watzke, Natalie; Wood, Phillip G.; Bamberg, Ernst; Nagel, Georg; Gottschalk, Alexander; Deisseroth, Karl (April 5, 2007). "Multimodal fast optical interrogation of neural circuitry".Nature.446 (7136):633–639.Bibcode:2007Natur.446..633Z.doi:10.1038/nature05744.PMID 17410168.S2CID 4415339.
  5. ^"Feng Zhang, Investigator".McGovern Institute for Brain Research. RetrievedJanuary 27, 2017.
  6. ^abZhang, Feng; Cong, Le; Lodato, Simona; Kosuri, Sriram; Church, George; Arlotta, Paola (January 19, 2011)."Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription".Nature Biotechnology.29 (2):149–153.doi:10.1038/nbt.1775.PMC 3084533.PMID 21248753.
  7. ^Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K (2010)."Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures".Nature Protocols.5 (3):439–56.doi:10.1038/nprot.2009.226.PMC 4503465.PMID 20203662.
  8. ^Zhang, Feng; Tsai, Hsing-Chen; Airan, Raag D.; Stuber, Garret D.; Adamantidis, Antoine R.; de Lecea, Luis; Bonci, Antonello; Deisseroth, Karl (2015). "Optogenetics in Freely Moving Mammals: Dopamine and Reward".Cold Spring Harbor Protocols.2015 (8):715–24.doi:10.1101/pdb.top086330.ISSN 1940-3402.PMID 26240415.
  9. ^"Method of the Year 2010".Nature Methods.8 (1): 1. 2010.doi:10.1038/nmeth.f.321.ISSN 1548-7091.
  10. ^Garneau, Josiane E.; Dupuis, Marie-Ève; Villion, Manuela; Romero, Dennis A.; Barrangou, Rodolphe; Boyaval, Patrick; Fremaux, Christophe; Horvath, Philippe; Magadán, Alfonso H.; Moineau, Sylvain (November 4, 2010). "The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA".Nature.468 (7320):67–71.Bibcode:2010Natur.468...67G.doi:10.1038/nature09523.hdl:20.500.11794/38818.PMID 21048762.S2CID 205222849.
  11. ^"Project Spotlight: CRISPR". December 17, 2014. RetrievedOctober 29, 2015.
  12. ^Cong, L.; Ran, F. A.; Cox, D.; Lin, S.; Barretto, R.; Habib, N.; Hsu, P. D.; Wu, X.; Jiang, W.; Marraffini, L. A.; Zhang, F. (January 3, 2013)."Multiplex Genome Engineering Using CRISPR/Cas Systems".Science.339 (6121):819–823.Bibcode:2013Sci...339..819C.doi:10.1126/science.1231143.PMC 3795411.PMID 23287718.
  13. ^Hsu, Patrick D; Scott, David A; Weinstein, Joshua A; Ran, F Ann; Konermann, Silvana; Agarwala, Vineeta; Li, Yinqing; Fine, Eli J; Wu, Xuebing; Shalem, Ophir; Cradick, Thomas J; Marraffini, Luciano A; Bao, Gang; Zhang, Feng (July 21, 2013)."DNA targeting specificity of RNA-guided Cas9 nucleases".Nature Biotechnology.31 (9):827–832.doi:10.1038/nbt.2647.PMC 3969858.PMID 23873081.
  14. ^Jinek, M.; Chylinski, K.; Fonfara, I.; Hauer, M.; Doudna, J. A.; Charpentier, E. (June 28, 2012)."A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity".Science.337 (6096):816–821.Bibcode:2012Sci...337..816J.doi:10.1126/science.1225829.PMC 6286148.PMID 22745249.
  15. ^Cong, L.; Ran, F. A.; Cox, D.; Lin, S.; Barretto, R.; Habib, N.; Hsu, P. D.; Wu, X.; Jiang, W.; Marraffini, L. A.; Zhang, F. (January 3, 2013)."Multiplex Genome Engineering Using CRISPR/Cas Systems".Science.339 (6121):819–823.Bibcode:2013Sci...339..819C.doi:10.1126/science.1231143.PMC 3795411.PMID 23287718.
  16. ^Hsu, Patrick D; Scott, David A; Weinstein, Joshua A; Ran, F Ann; Konermann, Silvana; Agarwala, Vineeta; Li, Yinqing; Fine, Eli J; Wu, Xuebing; Shalem, Ophir; Cradick, Thomas J; Marraffini, Luciano A; Bao, Gang; Zhang, Feng (July 21, 2013)."DNA targeting specificity of RNA-guided Cas9 nucleases".Nature Biotechnology.31 (9):827–832.doi:10.1038/nbt.2647.PMC 3969858.PMID 23873081.
  17. ^Isaacson, Walter (2021).The Code Breaker.Simon & Schuster. p. 209.ISBN 978-1-9821-1585-2.
  18. ^"Arbor Biotechnologies comes out of stealth with new CRISPR enzyme".FierceBiotech. March 15, 2018. RetrievedMay 16, 2021.
  19. ^Gootenberg, Jonathan S.; Abudayyeh, Omar O.; Lee, Jeong Wook; Essletzbichler, Patrick; Dy, Aaron J.; Joung, Julia; Verdine, Vanessa; Donghia, Nina; Daringer, Nichole M.; Freije, Catherine A.; Myhrvold, Cameron; Bhattacharyya, Roby P.; Livny, Jonathan; Regev, Aviv; Koonin, Eugene V.; Hung, Deborah T.;Sabeti, Pardis C.; Collins, James J.; Zhang, Feng (2017)."Nucleic acid detection with CRISPR-Cas13a/C2c2".Science.356 (6336):438–442.Bibcode:2017Sci...356..438G.doi:10.1126/science.aam9321.ISSN 0036-8075.PMC 5526198.PMID 28408723.
  20. ^"Sherlock Biosciences Inc".www.bloomberg.com. RetrievedMay 16, 2021.
  21. ^Hale, Conor (April 30, 2018)."Feng Zhang quietly starting new CRISPR-based company: report".FierceBiotech. RetrievedDecember 13, 2021.
  22. ^Isaacson, Walter (2021).The Code Breaker.Simon & Schuster. p. 462.ISBN 978-1-9821-1585-2.
  23. ^Rotman, David (2013)."Genomic research may finally help dispel the ignorance shrouding many types of mental illness".MIT Technology Review. RetrievedJanuary 27, 2017.
  24. ^"Stanford and MIT scientists win Perl-UNC Neuroscience Prize".UNC School of Medicine. Archived fromthe original on August 26, 2017. RetrievedJanuary 27, 2017.Development and Application of Optogenetics for Studying Neural Circuit Functions
  25. ^"Alan T. Waterman Award Recipients".NSF. Archived fromthe original on March 2, 2015. RetrievedJanuary 27, 2017.For development and application of molecular technologies that enable systematic interrogation of intact biological systems through precise genomic manipulation.
  26. ^"Past Winners | Gabbay Award | Rosenstiel Basic Medical Sciences Research Center".Brandeis University. RetrievedJanuary 27, 2017.
  27. ^"Feng Zhang, Diana Bautista Receive Young Investigator Award".SfN. RetrievedJanuary 27, 2017.
  28. ^"Program and Abstracts of the 12th Transgenic Technology Meeting (TT2014): The Assembly Rooms, Edinburgh, Scotland, United Kingdom, 6–8 October 2014".Transgenic Research.23 (5):827–909. October 1, 2014.doi:10.1007/s11248-014-9820-1.ISSN 0962-8819.S2CID 255104172.
  29. ^"Tsuneko & Reiji Okazaki Award – Feng Zhang".Nagoya University.
  30. ^"Canada Gairdner International Award". Archived fromthe original on March 29, 2016.
  31. ^"2016 Tang Prize in Biopharmaceutical Science". RetrievedJanuary 27, 2017.for the development of CRISPR/Cas9 as a breakthrough genome editing platform that promises to revolutionize biomedical research and disease treatment
  32. ^"The Asian Scientist 100".Asian Scientist. RetrievedMarch 13, 2025.
  33. ^"Albany Medical Center Prize 2017". RetrievedDecember 13, 2021.
  34. ^"Lemelson-MIT Prize 2017". Archived fromthe original on October 11, 2018. RetrievedDecember 13, 2021.
  35. ^"Feng Zhang".American Academy of Arts & Sciences. December 4, 2021. RetrievedDecember 13, 2021.
  36. ^"May 1, 2018 NAS Election".National Academy of Sciences. May 1, 2018. RetrievedDecember 13, 2021.
  37. ^"Six with MIT ties elected to the National Academy of Medicine for 2021".MIT News | Massachusetts Institute of Technology. October 20, 2021. RetrievedJanuary 5, 2022.
  38. ^Harvey Prize 2018
  39. ^"Golden Plate Awardees".Academy of Achievement. November 30, 2021. RetrievedDecember 13, 2021.
  40. ^"The Nobel Prize in Chemistry 2020". Nobel Foundation.Archived from the original on October 7, 2020. RetrievedOctober 7, 2020.
  41. ^Carter, Jane (January 21, 2021)."Four MIT Scientists Honored with 2021 National Academy of Science Awards".MIT News (chemistry.mit.edu).
  42. ^The White House (January 3, 2025)."President Biden Honors Nation's Leading Scientists, Technologists, and Innovators".The White House. RetrievedJanuary 4, 2025.

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