 | |
| Names | |
|---|---|
| IUPAC name (R/S)-2,4′-Dichloro-α-(pyrimidin-5-yl)benzhydryl alcohol | |
| Other names α-(2-Chlorophenyl)-α-(4-chlorophenyl)-5-pyrimidinemethanol | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.056.432 |
| UNII | |
| |
| |
| Properties | |
| C17H12Cl2N2O | |
| Molar mass | 331.20 g·mol−1 |
| Appearance | Colorless powder with aromatic odor |
| Melting point | 117 to 119 °C (243 to 246 °F; 390 to 392 K)[1] |
| Boiling point | 240 °C (464 °F; 513 K) (decomposition)[1] |
| 13.7 mg/L at 25 °C | |
| Solubility in other solvents | Soluble in acetone, xylene and methanol[1] |
| Vapor pressure | 65 μ Pa (25 °C)[1] |
| Hazards | |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | >2000 mg·kg−1 (oral, Rat)[1] |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Fenarimol, sold under the tradenamesBloc,Rimidin andRubigan, is afungicide which acts againstrusts,blackspot andmildew fungi. It is used onornamental plants, trees,lawns, tomatoes, peppers, eggplants,cucumbers and melons. It is mainly used to control powdery mildew. It works by inhibiting the fungus'sbiosynthesis of importantsteroid molecules (via blockade of theCYP51 enzyme).[2]
Fenarimol was developed byEli Lilly and Company around 1971.[3]
As of early 2018, derivatives of this compound are being researched in anopen source manner for possible treatment ofeumycetoma.[4]
Fenarimol is made by the reaction of 2,4'-dichlorobenzophenone with anorganolithiumpyrimidine made via bromine-lithium exchange.[2]
