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Farglitazar

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Chemical compound

Pharmaceutical compound

Farglitazar
Clinical data

Pregnancy category	N/A
ATC code	none
Legal status
Legal status	Development discontinued
Identifiers
IUPAC name N-(o-Benzoylphenyl)-O-[2-(5-methyl- 2-phenyl-4-oxazolyl)ethyl]-L-tyrosine
CAS Number	196808-45-4^Y
PubChemCID	170364
IUPHAR/BPS	2672
ChemSpider	148961^Y
UNII	3433GY7132
KEGG	D04132
ChEMBL	ChEMBL107367^Y
CompTox Dashboard(EPA)	DTXSID1047310
Chemical and physical data
Formula	C₃₄H₃₀N₂O₅
Molar mass	546.623 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccccc1)c2ccccc2N[C@H](C(=O)O)Cc5ccc(OCCc3nc(oc3C)c4ccccc4)cc5
InChI InChI=1S/C34H30N2O5/c1-23-29(36-33(41-23)26-12-6-3-7-13-26)20-21-40-27-18-16-24(17-19-27)22-31(34(38)39)35-30-15-9-8-14-28(30)32(37)25-10-4-2-5-11-25/h2-19,31,35H,20-22H2,1H3,(H,38,39)/t31-/m0/s1^N Key:ZZCHHVUQYRMYLW-HKBQPEDESA-N^N
^NY (what is this?) (verify)

Farglitazar is aperoxisome proliferator-activated receptor agonist which was formerly underdevelopment byGlaxoSmithKline, but has never been marketed. It progressed tophase II clinical trials for the treatment ofhepatic fibrosis, but failed to show efficacy.^[1] After reaching phase III fortype 2 diabetes, further development was discontinued.^[2]^[3]

References

[edit]

^McHutchison J, Goodman Z, Patel K, Makhlouf H, Rodriguez-Torres M, Shiffman M, et al. (April 2010). "Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection".Gastroenterology.138 (4):1365–73, 1373.e1-2.doi:10.1053/j.gastro.2009.12.003.PMID 20004661.
^"Farglitazar".Adis Insight. Springer Nature Switzerland AG.
^"Farglitazar". pharmacodia.com.

v t e PPARTooltip Peroxisome proliferator-activated receptormodulators
PPARαTooltip Peroxisome proliferator-activated receptor alpha	Agonists:15-HETE 15-HpETE Aleglitazar Aluminium clofibrate Arachidonic acid Bezafibrate Chiglitazar Clofibrate CP-775146 Daidzein DHEA (prasterone) (in rodents) Elafibranor Etomoxir Fenofibrate Genistein Gemfibrozil GW-7647 Lanifibranor Leukotriene B₄ LG-101506 LG-100754 Lobeglitazone Muraglitazar Oleylethanolamide Palmitoylethanolamide Pemafibrate Perfluorononanoic acid Perfluorooctanoic acid Pioglitazone Saroglitazar Sodelglitazar Tesaglitazar Tetradecylthioacetic acid Troglitazone WY-14643 Antagonists:GW-6471 MK-886
PPARδTooltip Peroxisome proliferator-activated receptor delta	Agonists:15-HETE 15-HpETE Arachidonic acid Bezafibrate Daidzein Elafibranor Fonadelpar Genistein GW-0742 GW-501516 L-165,041 Lanifibranor LG-101506 Seladelpar Sodelglitazar Tetradecylthioacetic acid Antagonists:FH-535 GSK-0660 GSK-3787
PPARγTooltip Peroxisome proliferator-activated receptor gamma	Agonists:5-Oxo-ETE 5-Oxo-15-hydroxy-ETE 15-Deoxy-Δ^12,14-prostaglandin J₂ 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Chiglitazar Ciglitazone Daidzein Darglitazone Edaglitazone Efatutazone Englitazone Etalocib Farglitazar Genistein GW-1929 Ibuprofen Imiglitazar Indeglitazar Lanifibranor LG-100268 LG-100754 LG-101506 Lobeglitazone Muraglitazar (muroglitazar) nTZDpa Naveglitazar Netoglitazone Oxeglitazar Peliglitazar Pemaglitazar Perfluorononanoic acid Pioglitazone Prostaglandin J₂ Ragaglitazar Reglitazar Rivoglitazone Rosiglitazone RS5444 Saroglitazar Sipoglitazar Sodelglitazar Telmisartan Tesaglitazar Troglitazone SPPARMsTooltip Selective PPARγ modulator:BADGE EPI-001 INT-131 MK-0533 S26948 Antagonists:FH-535 GW-9662 SR-202 T-0070907 Unknown:SR-1664
Non-selective	Agonists:Ciprofibrate Clinofibrate Clofibride Englitazone Etofibrate Farglitazar Netoglitazone Ronifibrate Rivoglitazone Simfibrate
See also Receptor/signaling modulators

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