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Famprofazone

From Wikipedia, the free encyclopedia
NSAID analgesic medication
Pharmaceutical compound
Famprofazone
Clinical data
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3H-pyrazol-3-one
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.041.153Edit this at Wikidata
Chemical and physical data
FormulaC24H31N3O
Molar mass377.532 g·mol−1
3D model (JSmol)
  • O=C2\C(=C(/N(N2c1ccccc1)C)CN(C(C)Cc3ccccc3)C)C(C)C

Famprofazone (Gewodin,Gewolen) is anonsteroidal anti-inflammatory agent (NSAID) of thepyrazolone series which is availableover-the-counter in some countries such asTaiwan.[1][2][3] It hasanalgesic,anti-inflammatory, andantipyretic effects.[1][2] Famprofazone has been known to producemethamphetamine as anactivemetabolite, with 15–20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives ondrug tests foramphetamines.[3]

See also

[edit]

References

[edit]
  1. ^abSwiss Pharmaceutical Society (2000).Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932.ISBN 3-88763-075-0.
  2. ^abHall JA, Morton I (1999).Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342.ISBN 0-7514-0499-3.
  3. ^abChan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse".Journal of Analytical Toxicology.34 (6):347–353.doi:10.1093/jat/34.6.347.PMID 20663288.
  4. ^Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man".Xenobiotica; the Fate of Foreign Compounds in Biological Systems.22 (3):377–384.doi:10.3109/00498259209046649.PMID 1496827.
  5. ^Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998)."Identification of new urinary metabolites of famprofazone in humans".Journal of Analytical Toxicology.22 (1):55–60.doi:10.1093/jat/22.1.55.PMID 9491970.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
Opioids
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Phenethylamines
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