Fabiola León-Velarde Servetto (Lima, June 18, 1956) is aPeruvianphysiologist who has devoted her research to thebiology and physiology of high altitude adaptation. Born in Lima, Peru. She is the daughter of Carlos Leon-Velarde Gamarra and Juana Servetto Marti from Uruguay, and granddaughter of Angelica Gamarra. Under the mentorship of high altitude physiologistCarlos Monge Cassinelli, she obtained a BSc. in Biology (1979), an MSc (1981) and DSc (1986) in physiology atCayetano Heredia University inLima, Perú.
She was Rector of theCayetano Heredia University (UPCH).[1] She was previously Vice-President for Research of UPCH and Chairwoman of the Department of Biological and Physiological Sciences at the same university. She has also been Vice-President of theInternational Society for Mountain Medicine and, during nine years has been doing collaborative research with the Human Respiratory Section of the Laboratory of Physiology of theUniversity of Oxford in theUnited Kingdom, where she has been invited as "Fellow" of the "Queen's College". At the moment, she is also Associated Investigator of ARPE/UFR of Medicine of theUniversity of Paris XIII inFrance.
Leon-Velarde has a vast scientific production that has been published in more than 80 abstracts and more than 100 peer-reviewed articles in international scientific journals. She is also author of chapters in several books aboutaltitude sickness and related topics particularly in the Andes. She is a member of important scientific societies such asThe American Physiological Society and theAcademy of Sciences of Latin America.
León-Velarde F., M. Vargas, M. Rivera-Chira y C. Monge C. Futbol y aclimatación a la altura. [Acta Andina][1]. 8(1/2): 23-29, 1999/2000.
León-Velarde F., A. Gamboa., J.A. Chuquiza, W.A. Esteba, M. Rivera-Ch. and C. Monge C.Hematological parameters in high altitude Andean Residents living at 4355, 4660 and 5500 meters above sea level. [High Altitude Med&Biol][2]. 1(2): 97-104, 2000.
León-Velarde F., M. Rivera-Chira, J-A. Palacios, R. Tapia, Huicho L., and C. Monge C. Relationship of ovarian hormones tohypoxemia in women resident of 4,300 m. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280(2): R488-R493, 2001.
Vargas, M., D. Jimenez, F. León-Velarde, J. Osorio and J.P. Mortola.Circadian patterns in men acclimatized to intermittent hypoxia. Respir Physiol. 126: 233-243, 2001.
Monge C., León-Velarde F., and A. Arregui.Chronic mountain sickness. In: High Altitude. An Exploration of Human Adaptation. Series: Lung Biology in Health and Disease. Edited by C. Lenfant. Marcel Dekker, Inc. N.Y. pp. 815–838, 2001.
Gamboa, A., F. León-Velarde, M. Rivera-Ch, M. Vargas, J-A. Palacios and C. Monge C. Ventilatory and cardiovascular responses tohypoxia in Andean natives living at sea level. [High Alt. Med. & Biol][3]. 2(3): 341-349, 2001.
Huicho, L., I.G. Pawson, F. León-Velarde, M. Rivera-Chira, A. Pacheco, M. Muro, and J. Silva.Oxygen saturation and heart rate in healthy school children and adolescents living athigh altitude. [Am. J. Hum. Biol.][4] 13:761-770, 2001.
León-Velarde F. and J. Reeves. International Working Group for Chronic Mountain Sickness. Meeting Minutes. In: Hypoxia from Genes to the Bedside, Advances in Exp. Med. & Biol. Chapter 28. Vol. 502: 439-440, 2001.
Keyl, C., A. Schneider, A. Gamboa, L. Spicuzza, N. Casiraghi, A. Mori, R.
Tapia Ramirez, F. León-Velarde, L. Bernardi. Modulation of autonomiccardiovascular function in Andean high-altitude natives with and withoutchronic mountain sickness. J. Appl Physiol. 2003 94(1): 213-219, 2003.
Gamboa A, León-Velarde F, Rivera-Ch M, Palacios J-A, Pragnell T.R, O’Connor D. and Robbins P.A. Acute and sustained ventilatory responses to hypoxia in high altitude natives living at sea level. [J. Applied Physiol.][5]Archived 2017-12-03 at theWayback Machine 94(3): 1255-1262, 2003.
Rivera-Ch M, Gamboa A, León-Velarde F, Palacios J-A, O’Connor D. and Robbins P.A. High altitude natives living at sea level acclimatize tohigh altitude like sea level natives. [J. Applied Physiol.][6]Archived 2017-12-03 at theWayback Machine 94(3): 1263-1268, 2003.
León-Velarde F, Gamboa A, Rivera-Ch M, Palacios J-A, and Robbins P.A. Peripheral chemoreflex function inhigh altitude natives and patients withchronic mountain sickness. [J. Applied Physiol.][7]Archived 2017-12-03 at theWayback Machine 94(3): 1269-1278, 2003.
Fatemian M, Gamboa A, León-Velarde F, Rivera-Ch M, Palacios J-A, and Robbins P.A. Ventilatory response to CO2 inhigh altitude natives and patients withchronic mountain sickness. [J. Applied Physiol.][8]Archived 2017-12-03 at theWayback Machine 94(3): 1279-1287, 2003.
Gamboa J, Macarlupu JL, Rivera-Chira M, Monge-C C, León-Velarde F. Effect of domperidone on ventilation andpolycythemia after 5 weeks of chronic hypoxia in rats. [Respir Physiolo Neurobiol.][9] 135(1):1-8, 2003.
León-Velarde F. Pursuing International recognition of Chronic Mountain Sickness. [High Alt. Med. & Biol][10]. 4(2): 256-259, 2003.
Brutsaert TD, Parra EJ, Shriver MD, Gamboa A, Palacios JA, Rivera M, Rodriquez I, León-Velarde F. Spanish genetic admixture is associated with larger VO2max decrement from sea level to 4,338 meters in PeruvianQuechua. [J Appl Physiol.][11]Archived 2017-12-03 at theWayback Machine 95(2) : 519-528, 2003.
Maggiorini M, León-Velarde F. High-altitudepulmonaryhypertension : a pathophysiological entity to different diseases. [Eur Respir J.][12] 22 : 1019-1025, 2003.
León-Velarde F, McCullough RG, McCullough RE, Reeves JT; CMS Consensus Working Group. Proposal for scoring severity inchronic mountain sickness (CMS). Background and conclusions of the CMS Working Group. Adv Exp Med Biol. 2003;543:339-54.
Bernardi L, Roach RC, Keyl C, Spicuzza L, Passino C, Bonfichi M, Gamboa A, Gamboa J, Malcovati L, Schneider A, Casiraghi N, Mori A, León-Velarde F. Ventilation, autonomic function, sleep anderythropoietin.Chronic mountain sickness of Andean natives. Adv Exp Med Biol. 2003;543:161-75.
Monge C. C. y F. León-Velarde. El Reto Fisiológico de Vivir en los Andes. Tomo 177. Travaux del Institut Francais d'Etudes Andines (IFEA). Editores, IFEA/ Universidad Peruana Cayetano Heredia. Lima, 2003, IFEA/UPCH. p.p. 435.
Spicuzza L, Casiraghi N, Gamboa A, Keyl C, Schneider A, Mori A, León-Velarde F, Di Maria GU, Bernardi L. Sleep-relatedhypoxaemia and excessiveerythrocytosis in Andeanhigh altitude natives. [Eur Respir J][13]. 2004; 23(1):41-46.
Brutsaert TD, Parra E, Shriver M, Gamboa A, Palacios JA, Rivera M, Rodriguez I, León-Velarde F. Effects of birthplace and individual genetic admixture on lung volume and exercise phenotypes of PeruvianQuechua. [Am J Phys Anthropol][14]. 2004; 123(4): 390-398.
Reeves JT and León-Velarde F. Chronic Mountain Sickness: Recent studies of the relationship between hemoglobin concentration andoxygen transport. [High Alt. Med and Biol][15]. 2004; 5(2): 147-155.
Claydon V.E., L.J. Norcliffe, J.P. Moore, M. Rivera-Ch, F. León-Velarde, O. Appenzeller and R. Hainsworth. Orthostatic tolerance and blood volumes in Andean high altitude dwellers. [Exp Physiol][16]. 2004; 89(5): 565-571.
Mejia OM, Prchal JT, León-Velarde F, Hurtado A, Stockton DW. Genetic association analysis ofchronic mountain sickness in an Andeanhigh altitude population. [Haematologica][17]. 90(1):13-19, 2005.
Claydon VE, Norcliffe LJ, Moore JP, Rivera M, León-Velarde F, Appenzeller O, Hainsworth R. Cardiovascular responses toorthostatic stress in healthy altitude dwellers, and altitude residents withchronic mountain sickness. [Exp Physiol][18]. 90(1):103-110, 2005.