This gene is a member of thefrizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to thebeta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.[7]
The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.[8][9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21".Biochem Biophys Res Commun.271 (1):8–14.doi:10.1006/bbrc.2000.2578.PMID10777673.
^Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)".Biochem Biophys Res Commun.273 (1):27–34.doi:10.1006/bbrc.2000.2882.PMID10873558.
Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells".Biochem. Biophys. Res. Commun.263 (2):384–8.doi:10.1006/bbrc.1999.1344.PMID10491302.
Zhang Y, Yu X, Yuan Y, Ling Y, Ruan Y, Si T, Lu T, Wu S, Gong X, Zhu Z, Yang J, Wang F, Zhang D (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population".Am. J. Med. Genet. B Neuropsychiatr. Genet.129 (1):16–9.doi:10.1002/ajmg.b.30076.PMID15274031.S2CID33599450.
Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)".Ophthalmic Genet.25 (2):81–90.doi:10.1080/13816810490514270.PMID15370539.S2CID32817238.
Hashimoto R, Suzuki T, Iwata N, Yamanouchi Y, Kitajima T, Kosuga A, Tatsumi M, Ozaki N, Kamijima K, Kunugi H (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders".Journal of Neural Transmission.112 (2):303–7.doi:10.1007/s00702-004-0264-2.PMID15657645.S2CID22324795.
"Frizzled Receptors: FZD3".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2014-09-03. Retrieved2008-12-04.
