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Frizzled-2

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From Wikipedia, the free encyclopedia

(Redirected fromFZD2)

Protein found in humans

FZD2

Identifiers

Aliases

FZD2, Fz2, fz-2, fzE2, hFz2, frizzled class receptor 2, OMOD2

External IDs

OMIM:600667;MGI:1888513;HomoloGene:20377;GeneCards:FZD2;OMA:FZD2 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.31	Start	44,557,484bp^[1]
Band	17q21.31	End	44,561,262bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 E1	Start	102,495,222bp^[2]
Band	11\|11 E1	End	102,498,884bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ventricular zone

embryo

spinal ganglia

ganglionic eminence

stromal cell of endometrium

trigeminal ganglion

glomerulus

metanephric glomerulus

retinal pigment epithelium

right coronary artery

Top expressed in

external carotid artery

internal carotid artery

ureter

medullary collecting duct

mandibular prominence

vas deferens

fossa

maxillary prominence

condyle

ascending aorta

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	PDZ domain binding signal transducer activity protein binding transmembrane signaling receptor activity G protein-coupled receptor activity Wnt-protein binding Wnt-activated receptor activity
Cellular component	cytoplasm clathrin-coated endocytic vesicle membrane membrane focal adhesion plasma membrane integral component of membrane
Biological process	G protein-coupled receptor signaling pathway epithelial cell differentiation muscular septum morphogenesis ventricular septum morphogenesis cell-cell signaling membranous septum morphogenesis outflow tract morphogenesis positive regulation of DNA-binding transcription factor activity Wnt signaling pathway planar cell polarity pathway involved in neural tube closure positive regulation of transcription, DNA-templated multicellular organism development sensory perception of smell cell surface receptor signaling pathway inner ear receptor cell development hard palate development cochlea morphogenesis neuron differentiation canonical Wnt signaling pathway signal transduction beta-catenin destruction complex disassembly Wnt signaling pathway, calcium modulating pathway Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway positive regulation of G protein-coupled receptor signaling pathway
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2535


57265

Ensembl


ENSG00000180340


ENSMUSG00000050288

UniProt


Q14332


Q9JIP6

RefSeq (mRNA)


NM_001466


NM_020510

RefSeq (protein)


NP_001457


NP_065256

Location (UCSC)

Chr 17: 44.56 – 44.56 Mb

Chr 11: 102.5 – 102.5 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Frizzled-2(Fz-2) is aprotein that in humans is encoded by theFZD2gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of theFZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000180340 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000050288 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhao Z, Lee CC, Baldini A, Caskey CT (Nov 1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1".Genomics.27 (2):370–3.doi:10.1006/geno.1995.1060.PMID 7558010.
^Sagara N, Toda G, Hirai M, Terada M, Katoh M (Dec 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7".Biochem Biophys Res Commun.252 (1):117–22.doi:10.1006/bbrc.1998.9607.PMID 9813155.
^^a ^b"Entrez Gene: FZD2 frizzled homolog 2 (Drosophila)".

External links

[edit]

"Frizzled Receptors: FZD₂".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-04.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F:Frizzled &Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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