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FOXO6

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
FOXO6
Identifiers
AliasesFOXO6, forkhead box O6
External IDsOMIM:611457;MGI:2676586;HomoloGene:82395;GeneCards:FOXO6;OMA:FOXO6 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FOXO6
Genomic location for FOXO6
Band1p34.2Start41,361,922bp[1]
End41,383,590bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FOXO6
Genomic location for FOXO6
Band4|4 D2.1Start120,124,276bp[2]
End120,144,546bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • pituitary gland

  • anterior pituitary

  • testicle

  • muscle of thigh

  • right ovary

  • left ovary

  • left lobe of thyroid gland

  • body of uterus

  • placenta
Top expressed in
  • ganglionic eminence

  • Claustrum

  • ventricular zone

  • subdivision of hippocampus

  • quadriceps femoris muscle

  • nucleus accumbens

  • hippocampus proper

  • skeletal muscle tissue

  • cingulate gyrus

  • Region I of hippocampus proper
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

100132074

329934

Ensembl

ENSG00000204060
ENSG00000281518

ENSMUSG00000052135

UniProt

A0A1X9RU27

Q70KY4

RefSeq (mRNA)

NM_001291281

NM_194060

RefSeq (protein)

NP_001278210

NP_918949

Location (UCSC)Chr 1: 41.36 – 41.38 MbChr 4: 120.12 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box O6 is aprotein that in humans is encoded by the FOXO6gene.[5]

FoxO6 is expressed in the liver, skeletal muscle, and thehippocampus of the brain.[6] In the liver, FoxO6 normally promotesgluconeogenesis in the fasted state, butinsulin blocks Fox06 after feeding.[6] In a condition ofinsulin resistance, insulin fails to block FoxO6, resulting in continued gluconeogenesis even after feeding.[6]

References

[edit]
  1. ^abcENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000052135Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: Forkhead box O6".
  6. ^abcLee S, Dong HH (2017)."FoxO integration of insulin signaling with glucose and lipid metabolism".Journal of Endocrinology.233 (2):R67 –R79.doi:10.1530/JOE-17-0002.PMC 5480241.PMID 28213398.

Further reading

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