Hepatocyte nuclear factor 3-gamma (HNF-3G), also known asforkhead box protein A3 (FOXA3) ortranscription factor 3G (TCF-3G) is aprotein that in humans is encoded by theFOXA3gene.[5][6]
HNF-3G is a member of theforkhead class of DNA-binding proteins. Thesehepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin andtransthyretin, and they also interact withchromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[5]
^Mincheva A, Lichter P, Schütz G, Kaestner KH (February 1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4".Genomics.39 (3):417–9.doi:10.1006/geno.1996.4477.PMID9119385.
Rodríguez-Antona C, Bort R, Jover R, et al. (2003). "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma".Mol. Pharmacol.63 (5):1180–9.doi:10.1124/mol.63.5.1180.PMID12695546.S2CID34628968.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Navas MA, Vaisse C, Boger S, et al. (2000). "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis".Hum. Hered.50 (6):370–81.doi:10.1159/000022943.PMID10899756.S2CID24745151.
Lin B, Morris DW, Chou JY (1997). "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation".Biochemistry.36 (46):14096–106.doi:10.1021/bi9703249.PMID9369482.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
