The Fos gene family consists of 4 members:c-Fos,FOSB,FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.[5]
Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (March 1990). "Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation".Oncogene.5 (3):249–55.PMID2107490.
Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2) to chromosome 2p22-p23".Genomics.38 (1):72–5.doi:10.1006/geno.1996.0593.PMID8954781.
Outinen PA, Sood SK, Pfeifer SI, Pamidi S, Podor TJ, Li J, Weitz JI, Austin RC (August 1999). "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells".Blood.94 (3):959–67.doi:10.1182/blood.V94.3.959.415k20_959_967.PMID10419887.
Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD (June 2000). "Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors".Journal of Neuroimmunology.105 (1):78–90.doi:10.1016/S0165-5728(00)00195-8.PMID10713367.S2CID8547340.
Udalova IA, Kwiatkowski D (November 2001). "Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region".Biochemical and Biophysical Research Communications.289 (1):25–33.doi:10.1006/bbrc.2001.5929.PMID11708771.
