Filamin A, alpha (FLNA) is aprotein that in humans is encoded by theFLNAgene.[5][6]
The structure of Filamin A, alpha includes anactin binding N terminal domain, 24 internal repeats and 2 hinge regions.[7][8]
Actin-binding protein, orfilamin, is a 280-kD protein that crosslinksactin filaments into orthogonal networks in corticalcytoplasm and participates in the anchoring of membrane proteins for the actincytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed filamin that regulates the reorganization of the actin cytoskeleton by interacting withintegrins,transmembrane receptor complexes, andsecondary messengers.[9] At least 31 disease-causing mutations in this gene have been discovered.[10]
Interaction of FLNA with theBRCA1 protein is required for efficient regulation of early stages ofDNA repair processes.[11] FLNA is implicated in the control of the DNA repair process ofhomologous recombination andnon-homologous end joining.[11]
Filamin has been shown tointeract with:
