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FGI-106

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Chemical compound

Pharmaceutical compound

FGI-106
Legal status

Legal status	US: Investigational New Drug
Identifiers
IUPAC name N¹,N⁷-bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine
CAS Number	501081-38-5^Y
PubChemCID	432342
ChemSpider	382357
UNII	BRT994456W
CompTox Dashboard(EPA)	DTXSID701028028
Chemical and physical data
Formula	C₂₈H₃₈N₆
Molar mass	458.654 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCCNc(c2ccc14)cc(C)nc2c1ccc3c4nc(C)cc3NCCCN(C)C
InChI InChI=1S/C28H38N6/c1-19-17-25(29-13-7-15-33(3)4)23-11-10-22-21(27(23)31-19)9-12-24-26(18-20(2)32-28(22)24)30-14-8-16-34(5)6/h9-12,17-18H,7-8,13-16H2,1-6H3,(H,29,31)(H,30,32) Key:WJUPENLNVUCETH-UHFFFAOYSA-N

FGI-106 is a broad-spectrumantiviral drug developed as a potential treatment for enveloped RNA viruses, in particularviral hemorrhagic fevers from thebunyavirus,flavivirus andfilovirus families. It acts as an inhibitor which blocks viral entry into host cells. In animal tests FGI-106 shows both prophylactic and curative action against a range of deadly viruses for which few existing treatments are available, including the bunyaviruseshantavirus,Rift Valley fever virus andCrimean-Congo hemorrhagic fever virus, the flavivirusdengue virus, and the filovirusesEbola virus andMarburg virus.^[1]^[2]^[3]^[4]^[5]

^Aman MJ, Kinch MS, Warfield K, Warren T, Yunus A, Enterlein S, et al. (September 2009). "Development of a broad-spectrum antiviral with activity against Ebola virus".Antiviral Research.83 (3):245–51.doi:10.1016/j.antiviral.2009.06.001.PMID 19523489.
^Smith DR, Ogg M, Garrison A, Yunus A, Honko A, Johnson J, Olinger G, Hensley LE, Kinch MS (2010)."Development of FGI-106 as a broad-spectrum therapeutic with activity against members of the family Bunyaviridae".Virus Adaptation and Treatment: 9.doi:10.2147/VAAT.S6903.
^Basu A, Li B, Mills DM, Panchal RG, Cardinale SC, Butler MM, et al. (April 2011)."Identification of a small-molecule entry inhibitor for filoviruses".Journal of Virology.85 (7):3106–19.doi:10.1128/JVI.01456-10.PMC 3067866.PMID 21270170.
^Ippolito G, Feldmann H, Lanini S, Vairo F, Di Caro A, Capobianchi MR, Nicastri E (March 2012)."Viral hemorrhagic fevers: advancing the level of treatment".BMC Medicine.10: 31.doi:10.1186/1741-7015-10-31.PMC 3325866.PMID 22458265.
^Picazo E, Giordanetto F (February 2015). "Small molecule inhibitors of ebola virus infection".Drug Discovery Today.20 (2):277–86.doi:10.1016/j.drudis.2014.12.010.PMID 25532798.

Filoviridae

Ebolavirus

Outbreaks	1976 Sudan outbreak 1976 Zaire outbreak 2013−2016 West African Ebola virus epidemic Timeline Reported cases and deaths Responses United Nations Ebola Response Fund Operation United Assistance in Guinea in Liberia in Mali in Nigeria in Sierra Leone in Spain in the US in the UK Ouse to Ouse Tock Womey massacre Recent DR Congo outbreaks and epidemics 2014 2017 2018 Équateur Kivu epidemic 2020 Équateur 2021 North Kivu
Species	Bundibugyo ebolavirus BDBV Reston ebolavirus RESTV Sudan ebolavirus SUDV Taï Forest ebolavirus TAFV Zaire ebolavirus EBOV
Drug candidates	BCX4430 Brincidofovir DZNep Favipiravir FGI-103 FGI-104 FGI-106 JK-05 Lamivudine mAb114 TKM-Ebola(failed) Triazavirin ZMapp Vaccines cAd3-ZEBOV
Drugs	Vaccines rVSV-ZEBOV
Notable people	Ebola researchers William Close Jean-Jacques Muyembe-Tamfum Peter Piot Ebola patients Ameyo Adadevoh Kent Brantly Pauline Cafferkey Thomas Eric Duncan Salome Karwah Sheik Umar Khan Matthew Lukwiya Mayinga N'Seka Patrick Sawyer
Popular culture	The Hot Zone(1995 book byRichard Preston) Outbreak(1995 film) Ebola Syndrome(1996 film) Executive Orders(1996 novel) Ebola-chan(2014 meme) 93 Days(2016 film) The Hot Zone(2019 miniseries based on Preston book)
Miscellaneous	Ebola virus disease Ebola virus disease treatment research Ebola River

Marburgvirus

Outbreaks	1967 Marburg virus outbreak in West Germany 2017 Uganda Marburg virus outbreak 2021 Marburg virus disease outbreak in Guinea 2022 Marburg virus disease outbreak in Ghana 2023 Marburg virus disease outbreak in Equatorial Guinea 2023 Marburg virus disease outbreak in Tanzania 2024 Marburg virus disease outbreak in Rwanda
Species	Marburg marburgvirus MARV RAVV
Drug candidates	BCX4430 FGI-103 FGI-106
Popular culture	The Hot Zone(1995 book)
Miscellaneous	Marburg virus disease Marburg

Cuevavirus

Species	Lloviu cuevavirus (LLOV)

Dianlovirus

Species	Mengla virus (MLAV)

Striavirus

Species	Xilang striavirus

Thamnovirus

Species	Huangjiao thamnovirus

NS3/4A protease inhibitors (–previr)	Asunaprevir Boceprevir^‡ Ciluprevir^§ Danoprevir^† Faldaprevir^‡ Glecaprevir Grazoprevir Narlaprevir Paritaprevir Simeprevir Sovaprevir^† Telaprevir^‡ Vaniprevir Vedroprevir^§ Voxilaprevir
NS5A inhibitors (–asvir)	Coblopasvir Daclatasvir^# Elbasvir Ledipasvir Odalasvir^† Ombitasvir Pibrentasvir Ravidasvir^† Ruzasvir^† Samatasvir^† Velpatasvir
NS5B RNA polymerase inhibitors (–buvir)	Beclabuvir^† Bemnifosbuvir^† Dasabuvir^# Deleobuvir^§ Filibuvir^§ GS-6620^§ IDX-184^§ Setrobuvir^§ Sofosbuvir^# Tegobuvir^§ TMC-647055^§ Radalbuvir^† Uprifosbuvir^†
Combination drugs	Elbasvir/grazoprevir Glecaprevir/pibrentasvir Ledipasvir/sofosbuvir^# Ombitasvir/paritaprevir/ritonavir^# Sofosbuvir/daclatasvir Sofosbuvir/velpatasvir^# Sofosbuvir/velpatasvir/voxilaprevir

Anti-influenza agents

Multiple/general

Interferon	Interferon alfa 2b Peginterferon alfa-2a^# Peginterferon alfa-2b^#
3CL protease inhibitors (–trelvir)	Atilotrelvir Ensitrelvir^† Ibuzatrelvir Leritrelvir Lufotrelvir Nirmatrelvir^† (+ritonavir)^† Rupintrivir Simnotrelvir (+ritonavir^†)
RNA pol inhibitors	CMX521^§ Deuremidevir^† Favipiravir Galidesivir^† GS-441524^§ Remdesivir MK-608^§ Mericitabine^† Molnupiravir NITD008^§ Ribavirin^# Taribavirin^† Triazavirin Valopicitabine^†
Multiple/Unknown/Other	EICAR^§ Merimepodib^§ Moroxydine Presatovir^†

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