Fas-activated serine/threonine kinase is anenzyme that in humans is encoded by theFASTKgene.[5][6][7]
The protein encoded by this gene is a member of the serine/threonineprotein kinase family. This kinase was shown to be activated rapidly during Fas-mediatedapoptosis inJurkat cells. In response toFas receptor ligation, itphosphorylates the apoptosis-promoting nuclear RNA-binding proteinTIA1. The encoded protein is a strong inducer oflymphocyte apoptosis.
Twotranscript variants encoding differentisoforms have been found for this gene. The longer one is located in the cell nucleus and cytoplasm, and the shorter one is 34 amino acids at the N-terminus, which is transported to the mitochondrion.[8]
The mitochondrial FASTK isoform localizes in the mitochondrial granules, where it interacts with theGRSF1 protein and binds tomt-mRNAND6, the template of the only protein encoded on the light strand of the mitochondrial genome. In the case of FASTK deletion, it was observed loss of ND6 mt-mRNA and a 50-60% decrease in the activity of complex I of the respiratory chain. However,overexpression of this protein resulted in the stabilization of ND6 mt-mRNA[8][9]
Other variants exist, but their full-length natures have not yet been determined.[7]
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