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| Names | |
|---|---|
| IUPAC name tetrasodium (6E,6'E)-6,6-[(3,3'-dimethylbiphenyl-4,4'-diyl)di(1E)hydrazin-2-yl-1-ylidene]bis(4-amino-5-oxo-5,6-dihydronaphthalene-1,3-disulfonate) | |
| Identifiers | |
| |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.005.676 |
| KEGG |
|
| MeSH | Evans+blue |
| UNII | |
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| Properties | |
| C34H24N6Na4O14S4 | |
| Molar mass | 960.809 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
T-1824 orEvans blue, often incorrectly rendered asEvan's blue, is anazo dye that has a very high affinity forserum albumin. Because of this, it can be useful inphysiology in estimating the proportion ofbody water contained inblood plasma.[1] It fluoresces with excitation peaks at 470 and 540 nm and an emission peak at 680 nm.[2]
Evans blue dye has been used as aviability assay on the basis of its penetration into non-viable cells, although the method is subject to error because it assumes that damaged or otherwise altered cells are not capable of repair and therefore are not viable.[3]
Evans blue is also used to assess the permeability of theblood–brain barrier to macromolecules. Because serum albumin cannot cross the barrier and virtually all Evans blue is bound to albumin, normally the neural tissue remains unstained.[4] When the blood–brain barrier has been compromised, albumin-bound Evans blue enters the CNS.
Evans blue is pharmacologically active, acting as anegative allosteric modulator of theAMPA andkainate receptors and as aninhibitor ofvesicular glutamate transporters.[5][6] It also acts onP2 receptors.[7]
It was named afterHerbert McLean Evans, an American anatomist.[8]
