Eva Nogales | |
|---|---|
 Nogales in 2023 | |
| Born | May 16, 1965 (1965-05-16) (age 60) Colmenar Viejo,Madrid, Spain |
| Education | Autonomous University of Madrid (B.S.) University of Keele (PhD) |
| Occupation(s) | Biophysicist, professor |
| Known for | The first to determine the atomic structure oftubulin byelectron crystallography |
| Spouse | Howard Padmore |
| Children | 2 |
| Awards | Early Career Award,American Society for Cell Biology(2005) Chabot Science Award for Excellence(2006) Shaw Prize(2023) |
| Scientific career | |
| Institutions | University of California, Berkeley,Howard Hughes Medical Institute,Synchrotron Radiation Source |
Eva Nogales (born May 16, 1965)[citation needed] is a Spanish-Americanbiophysicist at theLawrence Berkeley National Laboratory and a professor at theUniversity of California, Berkeley, where she served as head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015–2020). She is aHoward Hughes Medical Institute investigator.
Nogales is a pioneer in usingelectron microscopy for the structural and functional characterization of macromolecular complexes. She usedelectron crystallography to obtain the first structure oftubulin and identify the binding site of the important anti-cancer drugtaxol. She is a leader in combiningcryo-EM, computational image analysis andbiochemical assays to gain insights into function and regulation of biological complexes andmolecular machines.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2]
Eva Nogales obtained her BS degree in physics from theAutonomous University of Madrid in 1988.[3] She later earned her PhD from theUniversity of Keele in 1992 while working at theSynchrotron Radiation Source under the supervision ofJoan Bordas.[3]
During her post-doctoral work in the laboratory of Ken Downing at theLawrence Berkeley National Laboratory, Eva Nogales was the first to determine the atomic structure oftubulin and the location of the taxol-binding site byelectron crystallography.[4][5][6] She became an assistant professor in the Department of Molecular and Cell Biology at theUniversity of California, Berkeley in 1998. In 2000 she became an investigator in theHoward Hughes Medical Institute. Ascryo-EM techniques became more powerful,[7] she became a leader in applying cryo-EM to the study of microtubule structure and function[8] and other largemacromolecular assemblies such aseukaryotic transcription and translation initiation complexes,[9][10] the polycomb complex PRC2, andtelomerase.[11]
Nogales is married to Howard Padmore and they have two children.[21]
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