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Etisulergine

From Wikipedia, the free encyclopedia

Pharmaceutical compound
Etisulergine
Clinical data
Other namesCQ-32084; CQ 32-084;N,N-Diethyl-N'-(6-methylergolin-8α-yl)sulfamide
Drug classDopamine agonist;Prolactin inhibitor;Antiparkinsonian agent
Identifiers
  • (6aR,9S,10aR)-9-(diethylsulfamoylamino)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H28N4O2S
Molar mass376.52 g·mol−1
3D model (JSmol)
  • CCN(CC)S(=O)(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)C
  • InChI=1S/C19H28N4O2S/c1-4-23(5-2)26(24,25)21-14-10-16-15-7-6-8-17-19(15)13(11-20-17)9-18(16)22(3)12-14/h6-8,11,14,16,18,20-21H,4-5,9-10,12H2,1-3H3/t14-,16+,18+/m0/s1
  • Key:YHEIHLVIKSTGJE-YXJHDRRASA-N

Etisulergine (INNTooltip International Nonproprietary Name; developmental code nameCQ-32084 orCQ 32-084) is adrug of theergoline family described as adopamine agonist,prolactin inhibitor, andantiparkinsonian agent which was never marketed.[1][2][3][4][5][6] It is closely related inchemical structure tolisuride and is also similar in structure tolysergic acid diethylamide (LSD).[1][2] Etisulergine was first described in the literature by at least 1977.[1][5]

See also

[edit]

References

[edit]
  1. ^abcElks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 524.ISBN 978-1-4757-2085-3. Retrieved30 June 2025.
  2. ^abNegwer M, Scharnow H (2001).Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. p. 1829.ISBN 978-3-527-30247-5. Retrieved30 June 2025.
  3. ^Milne GW (8 May 2018).Drugs: Synonyms and Properties: Synonyms and Properties. Routledge.ISBN 978-1-351-78989-9. Retrieved30 June 2025.
  4. ^Casagrande C, Bertolini G (1996). "Perspectives in the design and application of dopamine receptor agonists".Pharmacochemistry Library. Vol. 24. Elsevier. pp. 67–84.doi:10.1016/s0165-7208(96)80008-0.ISBN 978-0-444-82204-8. Retrieved30 June 2025.
  5. ^abFlückiger E, Briner U, Bürki HR, Marbach P, Wagner HR, Doepfner W (December 1979). "Two novel prolactin release-inhibiting 8 alpha-amino-ergolines".Experientia.35 (12):1677–1678.doi:10.1007/BF01953267.PMID 520501.
  6. ^Pakkenberg H, Jensen I (1983). "Treatment of Parkinson's disease with the ergoline derivatives CQ 32-084 and CU 32-085".Advances in Neurology.37:151–157.PMID 6344587.


D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists
Ergolines
(incl.lysergines)
Clavines
(6,8-dimethylergolines)
Lysergamides
(lysergic acid amides)
Ergopeptines
(peptide ergolines)
Partial ergolines
Related compounds
Natural sources


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