Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

Etidocaine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Etidocaine
Clinical data
Trade namesDuranest
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa603026
Pregnancy
category
Routes of
administration
Parenteral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilityn/a
MetabolismHepatic
Eliminationhalf-life2.5 hours
ExcretionRenal
Identifiers
  • N-(2,6-dimethylphenyl)-
    2-(ethyl(propyl)amino)butanamide
CAS Number
PubChemCID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.048.296Edit this at Wikidata
Chemical and physical data
FormulaC17H28N2O
Molar mass276.424 g·mol−1
3D model (JSmol)
  • O=C(Nc1c(C)cccc1C)C(CC)N(CC)CCC
  • InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20) checkY
  • Key:VTUSIVBDOCDNHS-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Etidocaine, marketed under the trade nameDuranest, is an amide-typelocal anesthetic given byinjection duringsurgical procedures andlabor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of use during dentistry is increased bleeding during surgery.[1]

Synthesis

[edit]
Patent:[2] 2-bromobutyryl chloride synthesis:[3]

The amide reaction between2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) givesEtidocaine (5).

References

[edit]
  1. ^Sisk AL (1992)."Long-acting local anesthetics in dentistry".Anesthesia Progress.39 (3):53–60.PMC 2148750.PMID 1308373.
  2. ^DE2162744 idem H Adams, G Kronberg, B Takman,U.S. patent 3,812,147 (1974 to Astra Pharma Prod).
  3. ^Org. Synth. 1950, 30, 62. DOI: 10.15227/orgsyn.030.0062

External links

[edit]
Esters by acid
Aminobenzoic
Benzoic
ArCO2- (not para-amino or Ph)
Amides
Combinations
Stub icon

Thisdrug article relating to thenervous system is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Etidocaine&oldid=1309309839"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp