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Ethylone

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Ethylone
Clinical data
Pregnancy
category
  • N (US)
Routes of
administration
Oral, nasal, IV
Legal status
Legal status
Identifiers
  • (RS)-1-(1,3-benzodioxol-5-yl)-2-(ethylamino)propan-1-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC12H15NO3
Molar mass221.256 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • CC(NCC)C(=O)c1ccc2OCOc2c1
  • InChI=1S/C12H15NO3/c1-3-13-8(2)12(14)9-4-5-10-11(6-9)16-7-15-10/h4-6,8,13H,3,7H2,1-2H3 ☒N
  • Key:MJEMIOXXNCZZFK-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Ethylone, also known as3,4-methylenedioxy-N-ethylcathinone (MDEC,βk-MDEA), is arecreationaldesigner drug of thephenethylamine,amphetamine, andcathinonechemical classes. It is theβ-ketoanalogue ofMDEA ("Eve"). Ethylone has only a short history of human use and is reported to be less potent than its relativemethylone.[citation needed] In the United States, it began to be found in cathinone products in late 2011.[3]

Very little data exists about the pharmacological properties, metabolism, and toxicity of ethylone, and although several ethylone-related deaths have been reported, the cause of death was not due to ingestion of ethylone.[3]

Pharmacokinetics

[edit]

Analysis of human and rat urine for the metabolites ofbk-amphetamines suggested that ethylone was degraded in the following metabolic steps:[4]

  1. N-deethylation to theprimary amine.
  2. Reduction of theketo moiety to the respectivealcohol.

Legal Status

[edit]

As of October 2015 Ethylone is a controlled substance in China.[5]

See also

[edit]

References

[edit]
  1. ^Anvisa (2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-07-25).Archived from the original on 2023-08-27. Retrieved2023-08-27.
  2. ^"Substance Details Ethylone". Retrieved2024-01-22.
  3. ^abLee D, Chronister CW, Hoyer J, Goldberger BA (September 2015)."Ethylone-Related Deaths: Toxicological Findings".Journal of Analytical Toxicology.39 (7):567–71.doi:10.1093/jat/bkv053.PMID 26025164.
  4. ^Meyer MR, Wilhelm J, Peters FT, Maurer HH (June 2010). "Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry".Analytical and Bioanalytical Chemistry.397 (3):1225–33.doi:10.1007/s00216-010-3636-5.PMID 20333362.S2CID 21471611.
  5. ^"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived fromthe original on 1 October 2015. Retrieved1 October 2015.
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