The dosage and effects are reported to be similar to those of methaqualone, but shorter acting and slightly weaker.Typical reports use between 50 and 500 mg of etaqualone, depending on desired effects. Old pharmaceutical formulations of Ethinazone were 350 mg tablets. Etaqualone is thought to act in a similar way to barbiturates and benzodiazepines by increasing the sensitivity of GABAA receptors[citation needed]. Recreational effects include euphoria, relaxation, increased sociability and sexuality, reduction of short-term memory, and loss of coordination. Combination with other depressants has a potentiating effect and can cause overdose. Tolerance to benzodiazepines oralcohol will also reduce effects.
Ethaqualone can be present as a free base, insoluble in water but soluble in alcohol and nonpolar solvents, or as a water-soluble hydrochloride salt which is about 85% as potent as the freebase by weight[citation needed].
The most common route of administration of etaqualone is oral, but snorting the salt or smoking the free base have also been reported[citation needed].
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^GB patent 936902, "Quinazolinone Derivatives", issued 1963-09-18, assigned to Beiersdorf
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^Yang H, Dai L, Wang Y, Liu J, Qiu S, Gu J, Bai H, Wurita A, Liao L (November 2022). "Analytical method for detection and quantification of new emerging drug etaqualone in human blood and urine by gas chromatography tandem mass spectrometry".Legal Medicine (Tokyo, Japan).59 102125.doi:10.1016/j.legalmed.2022.102125.PMID35932525.
^Hongkun Y, Jinlei L, Lina D, Yue W, Junmei W, Wurita A (November 2021). "Detection and quantification of psychotropic drug etaqualone in human hair using GC-MS/MS".Legal Medicine (Tokyo, Japan).53 101964.doi:10.1016/j.legalmed.2021.101964.PMID34521032.
^"Etaqualone".Inxight Drugs. Retrieved7 August 2025.
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