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Etanautine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Etanautine
Clinical data
ATC code
Identifiers
  • 2-[di(phenyl)methoxy]-N,N-dimethylethanamine; 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid
CAS Number
ChemSpider
UNII
Chemical and physical data
FormulaC26H31N5O5
Molar mass493.564 g·mol−1
3D model (JSmol)
  • O=C2N(c1ncn(c1C(=O)N2C)CC(=O)O)C.O(CCN(C)C)C(c1ccccc1)c2ccccc2
  • InChI=1S/C17H21NO.C9H10N4O4/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h3-12,17H,13-14H2,1-2H3;4H,3H2,1-2H3,(H,14,15)
  • Key:UFKLOBYBVCBTBP-UHFFFAOYSA-N
  (verify)

Etanautine, also known asdiphenhydramine monoacefyllinate, is ananticholinergic used as anantiparkinsonian agent. It is a 1:1 salt ofdiphenhydramine withacefylline, similar to the diphenhydramine/8-chlorotheophylline combination productdimenhydrinate.[1]

As with dimenhydrinate, the stimulant effect of the etanautine counteracts the sedative effect from the diphenhydramine, resulting in an improved therapeutic profile.[2]

The 1:2 salt diphenhydramine diacefylline (with two molecules of acefylline to each molecule of diphenhydramine) is also used in medicine, under the brand nameNautamine.[1][3]

References

[edit]
  1. ^abSicari V, Zabbo CP (2022)."Diphenhydramine".StatPearls. Treasure Island (FL): StatPearls Publishing.PMID 30252266. Retrieved2022-11-02.
  2. ^Gonzalez F (August 21, 2009). "Diphenhydramine may be useful as a palliative treatment for patients dying with Parkinson's disease and tremors: a case report and discussion".The American Journal of Hospice & Palliative Care.26 (6):474–475.doi:10.1177/1049909109338937.PMID 19700649.S2CID 206633832.
  3. ^"Diphenhydramine Dosage Guide + Max Dose, Adjustments".Drugs.com. Retrieved2022-11-02.
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