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Etamivan

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Etamivan
Clinical data
Trade namesAnalepticon
ATC code
Identifiers
  • N,N-Diethyl-4-hydroxy-3-methoxybenzamide
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
ECHA InfoCard100.005.599Edit this at Wikidata
Chemical and physical data
FormulaC12H17NO3
Molar mass223.272 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)c1ccc(O)c(OC)c1
  • InChI=1S/C12H17NO3/c1-4-13(5-2)12(15)9-6-7-10(14)11(8-9)16-3/h6-8,14H,4-5H2,1-3H3 ☒N
  • Key:BQJODPIMMWWMFC-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Etamivan (INN, orethamivan (USAN); trade namesAnalepticon,Emivan, andVandid) is arespiratory stimulant drug[1] related tonikethamide. It was mainly used in the treatment ofbarbiturateoverdose[2] andchronic obstructive pulmonary disease,[3] but has now largely fallen into disuse.

Adverse effects which are common to the respiratory stimulant class include sneezing, coughing, andlaryngospasm when infused too rapidly. More serious adverse events include muscle twitching, tremors, and convulsions. The dose to treat barbiturate intoxication orcarbon dioxide narcosis in adults ranges from 0.5 mg/kg to 5.0 mg/kg, infused intravenously over several minutes. Epilepsy and the use ofmonoamine oxidase inhibitors or otheradrenergic drugs are contraindications.[4]

References

[edit]
  1. ^Hirsh K, Wang SC (May 1975). "Respiratory stimulant effects of ethamivan and picrotoxin".The Journal of Pharmacology and Experimental Therapeutics.193 (2):657–63.PMID 1173598.
  2. ^Wheeldon PJ, Perry AW (July 1963)."The use of ethamivan in the treatment of barbiturate poisoning".Canadian Medical Association Journal.89 (1):20–2.PMC 1921664.PMID 14000228.
  3. ^Sproule BJ, Jans RL, Breitkreutz H, Mahon W (December 1964)."Effects of ethamivan in patients with chronic respiratory disease".Canadian Medical Association Journal.91 (23):1203–8.PMC 1928498.PMID 14226094.
  4. ^American Medical Association Dept of Drugs (1977).AMA Drug Evaluations (3rd ed.). Littleton, Mass.: Pub. Sciences Group. p. N-61.ISBN 978-0-88416-175-2.OCLC 1024170745.
Adamantanes
Adenosine antagonists
Alkylamines
Ampakines
Arylcyclohexylamines
Benzazepines
Cathinones
Cholinergics
Convulsants
Eugeroics
Oxazolines
Phenethylamines
Phenylmorpholines
Piperazines
Piperidines
Phenethylpyrrolidines
Racetams
Psychedelics
Tropanes
Tryptamines
Others
Otherrespiratory system products (R07)
Lung surfactants
Respiratory stimulants
5-HT4 receptor agonists
Other agents for treating respiratory depression


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