Estrogen-related receptor gamma (ERR-gamma), also known asNR3B3 (nuclear receptor subfamily 3, group B, member 3), is anuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma)gene.[5][6][7] It behaves as a constitutive activator of transcription.[8]
Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in theplacenta, explaining reports of high bisphenol A accumulation there.[11]
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^Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR".Gene.228 (1–2):101–9.doi:10.1016/S0378-1119(98)00619-2.PMID10072763.
^abcdeMatsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (Oct 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma".Journal of Biochemistry.142 (4):517–24.doi:10.1093/jb/mvm158.PMID17761695.
^Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma".Biochemical and Biophysical Research Communications.426 (2):215–20.Bibcode:2012BBRC..426..215B.doi:10.1016/j.bbrc.2012.08.065.PMID22935422.
^Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (Jul 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform".Journal of Biochemistry.146 (1):113–22.doi:10.1093/jb/mvp049.PMID19304792.
Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants".Molecular Vision.8:205–20.PMID12107410.
Hentschke M, Süsens U, Borgmeyer U (Aug 2002). "Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding".European Journal of Biochemistry.269 (16):4086–97.doi:10.1046/j.1432-1033.2002.03102.x.PMID12180985.
Hentschke M, Schulze C, Süsens U, Borgmeyer U (Mar 2003). "Characterization of calmodulin binding to the orphan nuclear receptor Errgamma".Biological Chemistry.384 (3):473–82.doi:10.1515/BC.2003.053.PMID12715898.S2CID41163978.
Hentschke M, Borgmeyer U (Dec 2003). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma".Biochemical and Biophysical Research Communications.312 (4):975–82.Bibcode:2003BBRC..312..975H.doi:10.1016/j.bbrc.2003.11.025.PMID14651967.
Gao M, Sun P, Wang J, Zhao D, Wei L (2006). "Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma".International Journal of Gynecological Cancer.16 (2):827–33.doi:10.1111/j.1525-1438.2006.00527.x.PMID16681769.S2CID37213476.
Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma".Biochemical and Biophysical Research Communications.426 (2):215–20.Bibcode:2012BBRC..426..215B.doi:10.1016/j.bbrc.2012.08.065.PMID22935422.
