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Estrogen-related receptor beta

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

ESRRB

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1LO1

Identifiers

Aliases

ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2, Esrrb

External IDs

OMIM:602167;MGI:1346832;HomoloGene:69108;GeneCards:ESRRB;OMA:ESRRB - orthologs

Gene location (Human)

Chr.	Chromosome 14 (human)^[1]

Band	14q24.3	Start	76,310,712bp^[1]
Band	14q24.3	End	76,501,837bp^[1]

Gene location (Mouse)

Chr.	Chromosome 12 (mouse)^[2]

Band	12 D2\|12 40.49 cM	Start	86,407,891bp^[2]
Band	12 D2\|12 40.49 cM	End	86,568,402bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

human kidney

muscle of thigh

apex of heart

gastrocnemius muscle

left ventricle

renal medulla

body of stomach

right auricle of heart

skeletal muscle tissue

Top expressed in

neural layer of retina

stria vascularis

chorion

retinal pigment epithelium

vestibular sensory epithelium

morula

lumbar subsegment of spinal cord

blastocyst

secondary oocyte

ooblast

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	steroid binding nuclear receptor activity zinc ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding transcription factor binding metal ion binding steroid hormone receptor activity transcription coactivator activity protein binding RNA polymerase II complex binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Cellular component	nucleus nucleoplasm condensed chromosome integrator complex chromosome cytoplasm
Biological process	regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic placenta development transcription, DNA-templated steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter intracellular receptor signaling pathway stem cell population maintenance negative regulation of transcription by RNA polymerase II cell population proliferation stem cell division cell dedifferentiation photoreceptor cell maintenance positive regulation of transcription, DNA-templated inner ear development positive regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of transcription involved in G2/M transition of mitotic cell cycle positive regulation of stem cell population maintenance regulation of stem cell division negative regulation of stem cell differentiation positive regulation of glycogen biosynthetic process positive regulation of glycolytic process
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


2103


26380

Ensembl


ENSG00000119715


ENSMUSG00000021255

UniProt


O95718


Q61539

RefSeq (mRNA)


NM_004452 NM_001379180


NM_001159500 NM_011934

RefSeq (protein)


NP_004443 NP_001366109


NP_001152972 NP_036064

Location (UCSC)

Chr 14: 76.31 – 76.5 Mb

Chr 12: 86.41 – 86.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is anuclear receptor that in humans is encoded by theESRRB (Estrogen Related Receptor Beta)gene .^[5]

Function

[edit]

ESRRB has been shown to be vital for the transition between anaïve pluripotent and primed pluripotent state in mammalian cells, andNANOG controls the expression of ESRRB in this scenario.^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000119715 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021255 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: ESRRB estrogen-related receptor beta".
^Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I (November 2018)."Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation".The EMBO Journal.37 (21) e95476.doi:10.15252/embj.201695476.PMC 6213284.PMID 30275266.

Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors".Nature.331 (6151):91–94.Bibcode:1988Natur.331...91G.doi:10.1038/331091a0.PMID 3267207.S2CID 4275394.
Sladek R, Beatty B, Squire J, Copeland NG, Gilbert DJ, Jenkins NA, Giguère V (October 1997). "Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene".Genomics.45 (2):320–326.doi:10.1006/geno.1997.4939.PMID 9344655.
Enmark E, Pelto-Huikko M, Grandien K, Lagercrantz S, Lagercrantz J, Fried G, et al. (December 1997)."Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern".The Journal of Clinical Endocrinology and Metabolism.82 (12):4258–4265.doi:10.1210/jcem.82.12.4470.PMID 9398750.
Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, et al. (March 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR".Gene.228 (1–2):101–109.doi:10.1016/S0378-1119(98)00619-2.PMID 10072763.
Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM (December 1999)."Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2".Molecular Endocrinology.13 (12):2151–2162.doi:10.1210/mend.13.12.0381.PMID 10598588.
Gearhart MD, Holmbeck SM, Evans RM,Dyson HJ, Wright PE (April 2003). "Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition".Journal of Molecular Biology.327 (4):819–832.doi:10.1016/S0022-2836(03)00183-9.PMID 12654265.
Kruijver FP, Balesar R, Espila AM, Unmehopa UA, Swaab DF (November 2003). "Estrogen-receptor-beta distribution in the human hypothalamus: similarities and differences with ER alpha distribution".The Journal of Comparative Neurology.466 (2):251–277.doi:10.1002/cne.10899.PMID 14528452.S2CID 86143014.
Stossi F, Barnett DH, Frasor J, Komm B, Lyttle CR, Katzenellenbogen BS (July 2004)."Transcriptional profiling of estrogen-regulated gene expression via estrogen receptor (ER) alpha or ERbeta in human osteosarcoma cells: distinct and common target genes for these receptors".Endocrinology.145 (7):3473–3486.doi:10.1210/en.2003-1682.PMID 15033914.
Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (August 2004)."Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism".FASEB Journal.18 (11):1252–1254.doi:10.1096/fj.03-1088fje.PMID 15208259.S2CID 20159723.
Smith LH, Coats SR, Qin H, Petrie MS, Covington JW, Su M, et al. (August 2004). "Differential and opposing regulation of PAI-1 promoter activity by estrogen receptor alpha and estrogen receptor beta in endothelial cells".Circulation Research.95 (3):269–275.doi:10.1161/01.RES.0000136521.70093.f1.PMID 15217907.S2CID 43765339.
Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA (February 2005)."Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease".The Journal of Clinical Endocrinology and Metabolism.90 (2):1041–1046.doi:10.1210/jc.2004-1211.PMID 15536156.
Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, et al. (March 2005)."Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues".The Journal of Clinical Endocrinology and Metabolism.90 (3):1830–1844.doi:10.1210/jc.2004-1421.PMID 15598686.
Zhou W, Liu Z, Wu J, Liu JH, Hyder SM, Antoniou E, Lubahn DB (February 2006)."Identification and characterization of two novel splicing isoforms of human estrogen-related receptor beta".The Journal of Clinical Endocrinology and Metabolism.91 (2):569–579.doi:10.1210/jc.2004-1957.PMID 16332939.

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

This article on agene on humanchromosome 14 is astub. You can help Wikipedia byexpanding it.

v t e PDB gallery
1lo1: ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA

Transcription factors andintracellular receptors

(1) Basic domains

(1.1) Basicleucine zipper (bZIP)

Activating transcription factor
- AATF
- 1
- 2
- 3
- 4
- 5
- 6
- 7
AP-1
- c-Fos
- FOSB
- FOSL1
- FOSL2
- JDP2
- c-Jun
- JUNB
- JunD
BACH
- 1
- 2
BATF
BLZF1
C/EBP
- α
- β
- γ
- δ
- ε
- ζ
CREB
- 1
- 3
- L1
CREM
DBP
DDIT3
GABPA
GCN4
HLF
MAF
- B
- sMaf
  - F
  - G
  - K
NFE
- 2
- L1
- L2
- L3
NFIL3
NRL
NRF
- 1
- 2
- 3
XBP1

(1.2) Basic helix-loop-helix (bHLH)

Group A	AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5 MYF6 NeuroD 1 2 Neurogenins 1 2 3 OLIG 1 2 Paraxis TCF15 Scleraxis SLC LYL1 TAL 1 2 Twist
Group B	FIGLA Myc c-Myc l-Myc n-Myc MXD4 TCF4
Group C bHLH-PAS	AhR AHRR ARNT ARNTL ARNTL2 CLOCK HIF 1A EPAS1 3A NPAS 1 2 3 PER 1 2 3 Period SIM 1 2
Group D	BHLH 2 3 9 Pho4 ID 1 2 3 4
Group E	HES 1 2 3 4 5 6 7 HEY 1 2 L
Group F bHLH-COE	EBF1

(1.3)bHLH-ZIP

(1.4) NF-1

NFI
- A
- B
- C
- X
SMAD
- R-SMAD
  - 1
  - 2
  - 3
  - 5
  - 9
- I-SMAD
  - 6
  - 7
- 4)

(1.5) RF-X

RFX
- 1
- 2
- 3
- 4
- 5
- 6
- ANK

(1.6) Basic helix-span-helix (bHSH)

AP-2
- α
- β
- γ
- δ
- ε

(2)Zinc finger DNA-binding domains

(2.1)Nuclear receptor(Cys₄)

subfamily 1	Thyroid hormone α β CAR FXR LXR α β PPAR α β/δ γ PXR RAR α β γ ROR α β γ Rev-ErbA α β VDR
subfamily 2	COUP-TF (I II Ear-2 HNF4 α γ PNR RXR α β γ Testicular receptor 2 4 TLX
subfamily 3	Steroid hormone Androgen Estrogen α β Glucocorticoid Mineralocorticoid Progesterone Estrogen related α β γ
subfamily 4	NUR NGFIB NOR1 NURR1
subfamily 5	LRH-1 SF1
subfamily 6	GCNF
subfamily 0	DAX1 SHP

(2.2) Other Cys₄

GATA
- 1
- 2
- 3
- 4
- 5
- 6
MTA
- 1
- 2
- 3
TRPS1

(2.3) Cys₂His₂

General transcription factors
- TFIIA
- TFIIB
- TFIID
- TFIIE
  - 1
  - 2
- TFIIF
- 1
- 2
  - TFIIH
  - 1
  - 2
  - 4
  - 2I
  - 3A
  - 3C1
  - 3C2

ATBF1
BCL
- 6
- 11A
- 11B
CTCF
E4F1
EGR
- 1
- 2
- 3
- 4
ERV3
GFI1
GLI family
- 1
- 2
- 3
- REST
- S1
- S2
- YY1
HIC
- 1
- 2
HIVEP
- 1
- 2
- 3
IKZF
- 1
- 2
- 3
ILF
- 2
- 3
Sp/KLF family
- KLF
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - 7
  - 8
  - 9
  - 10
  - 11
  - 12
  - 13
  - 14
  - 15
  - 17
- SP
  - 1
  - 2
  - 4
  - 7
  - 8
MTF1
MYT1
OSR1
PRDM9
SALL
- 1
- 2
- 3
- 4
TSHZ3
WT1
Zbtb7
- 7A
- 7B
ZBTB
- 11
- 16
- 17
- 20
- 21
- 32
- 33
- 40
zinc finger
- 3
- 7
- 9
- 10
- 19
- 22
- 24
- 33B
- 34
- 35
- 41
- 43
- 44
- 51
- 74
- 143
- 146
- 148
- 165
- 202
- 217
- 219
- 238
- 239
- 259
- 267
- 268
- 281
- 300
- 318
- 330
- 346
- 350
- 365
- 366
- 384
- 423
- 451
- 452
- 471
- 593
- 638
- 644
- 649
- 655
- 804A

(2.4) Cys₆

HIVEP1

(2.5) Alternating composition

AIRE
DIDO1
GRLF1
ING
- 1
- 2
- 4
JARID
- 1A
- 1B
- 1C
- 1D
- 2
JMJD1B

(2.6) WRKY

WRKY

(3)Helix-turn-helixdomains

(3.1)Homeodomain

Antennapedia
ANTP class

protoHOX Hox-like	ParaHox Gsx 1 2 Xlox PDX1 Cdx 1 2 4 extended Hox:Evx1 Evx2 MEOX1 MEOX2 Homeobox A1 A2 A3 A4 A5 A7 A9 A10 A11 A13 B1 B2 B3 B4 B5 B6 B7 B8 B9 B13 C4 C5 C6 C8 C9 C10 C11 C12 C13 D1 D3 D4 D8 D9 D10 D11 D12 D13 GBX1 GBX2 MNX1
metaHOX NK-like	BARHL1 BARHL2 BARX1 BARX2 BSX DBX 1 2 DLX 1 2 3 4 5 6 EMX 1 2 EN 1 2 HHEX HLX LBX1 LBX2 MSX 1 2 NANOG NKX 2-1 2-2 2-3 2-5 3-1 3-2 HMX1 HMX2 HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2

other

ARX
CRX
CUTL1
FHL
- 1
- 2
- 3
HESX1
HOPX
LMX
- 1A
- 1B
NOBOX
TALE
- IRX
  - 1
  - 2
  - 3
  - 4
  - 5
  - 6
  - MKX
- MEIS
  - 1
  - 2
- PBX
  - 1
  - 2
  - 3
- PKNOX
  - 1
  - 2
- SIX
  - 1
  - 2
  - 3
  - 4
  - 5
PHF
- 1
- 3
- 6
- 8
- 10
- 16
- 17
- 20
- 21A
POU domain
- PIT-1
- BRN-3:A
- B
- C
- Octamer transcription factor:1
- 2
- 3/4
- 6
- 7
- 11
SATB2
ZEB
- 1
- 2

(3.2) Paired box

PAX
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
PRRX
- 1
- 2
PROP1
PHOX
- 2A
- 2B
RAX
SHOX
SHOX2
VSX1
VSX2
Bicoid
- GSC
- BICD2
- OTX
  - 1
  - 2
- PITX
  - 1
  - 2
  - 3

(3.3)Fork head /winged helix

E2F
- 1
- 2
- 3
- 4
- 5
FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1

(3.4)Heat shock factors

HSF
- 1
- 2
- 4

(3.5) Tryptophan clusters

ELF
- 2
- 4
- 5
EHF
ELK
- 1
- 3
- 4
ERF
ETS
- 1
- 2
- ERG
- SPIB
ETV
- 1
- 4
- 5
- 6
FLI1
Interferon regulatory factors
- 1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
MYB
MYBL2

(3.6) TEA domain

transcriptional enhancer factor
- 1
- 2
- 3
- 4

(4)β-Scaffold factors with minor groove contacts

(4.1)Rel homology region	NF-κB NFKB1 NFKB2 REL RELA RELB NFAT C1 C2 C3 C4 5
(4.2)STAT	STAT 1 2 3 4 5 6
(4.3) p53-like	p53 p63 p73 family p53 TP63 p73 TBX 1 2 3 5 19 21 22 TBR1 TBR2 TFT MYRF
(4.4)MADS box	Mef2 A B C D SRF
(4.6)TATA-binding proteins	TBP TBPL1
(4.7)High-mobility group	BBX HMGB 1 2 3 4 HMGN 1 2 3 4 HNF 1A 1B SOX 1 2 3 4 5 6 8 9 10 11 12 13 14 15 17 18 21 SRY SSRP1 TCF/LEF TCF 1 3 4 LEF1 TOX 1 2 3 4
(4.9) Grainyhead	TFCP2
(4.10) Cold-shock domain	CSDA YBX1
(4.11) Runt	CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA 1 2 HBP1
(0.3)Pocket domain	Rb RBL1 RBL2
(0.5)AP-2/EREBP-related factors	Apetala 2 EREBP B3
(0.6) Miscellaneous	ARID 1A 1B 2 3A 3B 4A CAP IFI 16 35 MLL 2 3 T1 MNDA NFY A B C Rho/Sigma

see alsotranscription factor/coregulator deficiencies

v t e Estrogen-related receptor modulators
ERRαTooltip Estrogen-related receptor alpha	Agonists:6,3′,4′-Trihydroxyflavone Biochanin A Bisphenol AF Cholesterol Daidzein Genistein SLU-PP-332 Antagonists:Diethylstilbestrol XCT-790
ERRβTooltip Estrogen-related receptor beta	Agonists:DY-131 (GSK-9089) GSK-4716 (GW-4716) SLU-PP-332 Antagonists:4-Hydroxytamoxifen (afimoxifene) Bisphenol AF Diethylstilbestrol
ERRγTooltip Estrogen-related receptor gamma	Agonists:Bisphenol A DY-131 (GSK-9089) GSK-4716 (GW-4716) SLU-PP-332 Antagonists:4-Hydroxytamoxifen (afimoxifene) Diethylstilbestrol
See also Receptor/signaling modulators

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