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Estrobin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Estrobin
Clinical data
ATC code
  • None
Identifiers
  • 1,1'-(2-Bromo-2-phenyl-1,1-ethenediyl)bis(4-ethoxybenzene)
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC24H23BrO2
Molar mass423.350 g·mol−1

Estrobin, also known asα,α-di(p-ethoxyphenyl)-β-phenylbromoethylene and commonly abbreviated asDBE, is asynthetic,nonsteroidalestrogen of thetriphenylethylene group that was never marketed.[1][2]Chlorotrianisene, and subsequentlyclomifene andtamoxifen, were derived from it.[1][2] Estrobin, similarly to other triphenylethylenes, is verylipophilic and hence very long-lasting in its duration of action.[1][2] Similarly to chlorotrianisene, estrobin behaves aprodrug to a much more potent estrogen in the body.[2]

See also

[edit]

References

[edit]
  1. ^abcJordan VC (1986).Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 23–.ISBN 978-0-299-10480-1.
  2. ^abcdWelsh AL (April 1954). "Use of synthetic estrogenic substance chlorotrianisene (TACE) in treatment of acne".Archives of Dermatology.69 (4):418–27.doi:10.1001/archderm.1954.01540160020004.PMID 13147544.
ERTooltip Estrogen receptor
Agonists
Mixed
(SERMsTooltip Selective estrogen receptor modulators)
Antagonists
GPERTooltip G protein-coupled estrogen receptor
Agonists
Antagonists
Unknown
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