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| Combination of | |
|---|---|
| Esterified estrogens | Estrogen |
| Methyltestosterone | Androgen;Anabolic steroid |
| Clinical data | |
| Trade names | Covaryx, Essian, Estratest, Menogen, Syntest |
| Other names | EEs/MT |
| Routes of administration | By mouth |
| Drug class | Estrogen;Androgen |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
Esterified estrogens/methyltestosterone (EEs/MT), sold under brand names such asCovaryx,Eemt,Essian,Estratest,Menogen, andSyntest, is ahormonal preparation that combinesesterified estrogens (EEs) withmethyltestosterone (MT) in one tablet and is used inmenopausal hormone therapy.[2]
EEs/MT is used to treatmenopausal women who suffer fromhot flashes, but do not get relief from estrogen-only therapy.
EEs/MT is sold in tablet form, with either 1.25 mg EEs/2.5 mg MT or 0.625 mg EEs/1.25 mg MT available.
The product is a combination ofesterified estrogens, anestrogen, and low-dosemethyltestosterone, anandrogen/anabolic steroid, in a single tablet.
EEs/MT was first marketed in the United States in 1965 by Reid-Provident Laboratories, which as 100% of Reid-Rowell, Inc. stock was acquired by the Belgian pharmaceutical companySolvay in 1986. There has been some controversy surrounding the drug in recent years as to its status with the U.S.Food and Drug Administration.
Solvay sponsored a clinical trial of EEs/MT in the United States to determine whether the product is superior to treatment with esterified estrogens tablets.
EEs/MT was supplied by Solvay. In March 2009 Solvay announced that, based on a variety of business factors, it would discontinue supplying Estratest and Estratest HS tablets, and would stop accepting orders for the product on March 31, 2009.