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| Other names | E2D; Estradiol decylate; Estradiol 17β-decanoate; Estra-1,3,5(10)-triene-3,17β-diol 17β-decanoate |
| Routes of administration | By mouth[1][2] |
| Drug class | Estrogen;Estrogen ester |
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| Chemical and physical data | |
| Formula | C28H42O3 |
| Molar mass | 426.641 g·mol−1 |
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Estradiol decanoate (E2D), orestradiol decylate, also known asestradiol 17β-decanoate, is asyntheticsteroidalestrogen and anestrogen ester – specifically, the 17β-decanoate (decylate)ester ofestradiol – which was studied for use inhormone replacement therapy forovariectomized women in the late 1970s but was never marketed.[1][2][3]
Oral estradiol decanoate inoil at a dosage of 0.25 to 0.5 mg/day for 14 days has been studied inovariectomized women and found to produce levels ofestrone and estradiol with a ratio of about 1:2 (0.5) to 1:1.7 (0.6).[1][2] This is in contrast to oral micronized estradiol, which has an estrone to estradiol ratio of about 5:1 (an 8- to 10-fold difference in ratio relative to oral estradiol decanoate in oil).[4] The normal ratio of estrone to estradiol in women is about 1:2 (0.5) in premenopausal women and about 2:1 in postmenopausal women.[4] As such, oral estradiol decanoate in oil may provide a more physiological and favorable profile of estrone and estradiol levels than oral micronized estradiol.[1][2]
The improved estrone to estradiol ratio of oral estradiol decanoate in oil is likely related toabsorption via theintestinallymphatic system, which allows for bypassing offirst-pass metabolism in theliver.[5] This is dependent on thefatty acid decanoate ester of estradiol decanoate, and in accordance, oral estradiol decanoate not dissolved in oil has less or absent effects in rodents.[5] Absorption of oral estradiol decanoate in oil via the lymphatic system is analogous to the case of oraltestosterone undecanoate in oil.[6]
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