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| Names | |
|---|---|
| IUPAC name 15,16-Dimethoxy-1,2,6,7-tetradehydroerythrinan-3β-ol | |
| Systematic IUPAC name (9bS,11R)-7,8-Dimethoxy-4,5,10,11-tetrahydro-2H-indolo[7a,1-a]isoquinolin-11-ol | |
| Identifiers | |
3D model (JSmol) | |
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| UNII | |
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| Properties | |
| C18H21NO3 | |
| Molar mass | 299.370 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Erythravine is atetrahydroisoquinolinealkaloid found in the plantErythrina mulungu and other species of the genusErythrina.
Some laboratory research has investigated thebiological activity of erythravine, but the relevance to effects in humans is unknown.
It has been shown to be a potentnicotinic receptorantagonist in animal models with anIC50 of 6μM at theα7 site and 13 nM for theα4β2 receptor.[1]
It appears to haveanxiolytic effects inanimal models of anxiety. Further studies suggest that theanxiolytic effects are only reproducible with the whole extract ofErythrina mulungu but not with the pure alkaloids.[2][3]
Erythravine inhibited seizures evoked bybicuculline,pentylenetetrazole, andkainic acid as well as increasing the latency of seizures induced byNMDA. Treatment with erythravine prevented death in all the animals tested with the fourconvulsants except a few of those treated with kainic acid.[4]
