Eric C. Leuthardt | |
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 Eric C. Leuthardt | |
| Born | (1973-05-23)May 23, 1973 (age 52) Boston, Massachusetts, U.S. |
| Alma mater | Saint Louis University (BS) University of Pennsylvania School of Medicine (MD) Washington University in St. Louis (MBA) |
| Known for | Brain–computer interfaces Laser interstitial thermal therapy Neuroprosthetics Focused ultrasound for brain tumors Resting-state fMRI brain mapping |
| Awards |
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| Scientific career | |
| Fields | Neurosurgery Neuroengineering Biomedical engineering |
| Institutions | Washington University School of Medicine |
Eric C. Leuthardt (born May 23, 1973) is an American neurosurgeon, neuroscientist, inventor, entrepreneur, and science-fiction author. He is known for pioneering contributions tobrain–computer interface (BCI) technology, minimally invasive neurosurgical techniques, and the clinical translation of resting-statefunctional magnetic resonance imaging (fMRI) for brain mapping.[1] As of November 2025, his research has been cited over 53,000 times according to Google Scholar.[2]
Leuthardt is the Shi H. Huang Professor of Neurological Surgery atWashington University School of Medicine in St. Louis, with additional appointments in neuroscience, biomedical engineering, and mechanical engineering & materials science. He serves as chief of the Division of Neurotechnology, director of the Center for Innovation in Neuroscience and Technology, director of the Brain Laser Center, and assistant vice chancellor for innovation and commercialization.[3] He holds more than 1,600 patent filings and applications worldwide, primarily in neurotechnology and neuromodulation.[4][5]
Leuthardt was born in Boston, Massachusetts, in May 1973, to a German father who worked in the automotive industry and an Italian mother who was a schoolteacher.[6] He lived briefly in Stuttgart, Germany, as a young child before growing up in Cincinnati, Ohio.[6][7] As a high school student in Cincinnati, he worked in a neuroscience laboratory at the University of Cincinnati, studying electromagnetic effects on neuron growth and observing neurosurgical procedures, which sparked his interest in the field.[6]
Leuthardt earned a Bachelor of Science in biology and theology fromSaint Louis University. He received his Doctor of Medicine from thePerelman School of Medicine at the University of Pennsylvania in 1999, completed his neurosurgery residency atBarnes-Jewish Hospital andWashington University School of Medicine, and undertook a fellowship in spinal and epilepsy surgery at theUniversity of Washington. He later obtained an MBA from theOlin Business School atWashington University in St. Louis.[3]
Leuthardt's clinical practice focuses on surgery for brain tumors and epilepsy. He has advanced minimally invasive techniques, including laser interstitial thermal therapy (LITT) and focused ultrasound.[3]
Leuthardt's laboratory pioneered the clinical use of resting-state fMRI for preoperative brain mapping in patients unable to perform task-based fMRI.[8] He also led the first-in-human "sonobiopsy" trial using focused ultrasound to non-invasively release tumor biomarkers into the bloodstream for liquid biopsy.[9]
Leuthardt has co-founded several neurotechnology companies to commercialize innovations from his research.
In 2008, he co-foundedNeurolutions, which developed the IpsiHand Upper Extremity Rehabilitation System—a non-invasive brain–computer interface that uses signals from the unaffected (ipsilateral) cerebral hemisphere to aid motor recovery in chronic stroke patients. The device received FDA De Novo authorization and Breakthrough Device designation in 2021.[10][11] In 2024, Neurolutions merged withKandu Health.[12]
He co-foundedSora Neuroscience, whose Cirrus platform uses resting-state fMRI for preoperative brain mapping in neurosurgery patients. The software received FDA 510(k) clearance in 2025.[13]
Other ventures includeAurenar (developing a wearable non-invasive vagus nerve stimulation device) andCaeli Vascular. As assistant vice chancellor for innovation and commercialization at Washington University, Leuthardt oversees technology transfer and startup creation in the medical school.[3][4]
Leuthardt's research focuses onelectrocorticography (ECoG)-based brain–computer interfaces, neuroprosthetics, and advanced neuroimaging. His early work demonstrated real-time ECoG control of computer cursors and virtual devices in humans.[14] Subsequent studies established the use of ipsilateral motor signals for BCI applications in hemiplegic stroke survivors.[15]
Leuthardt is the author of the science-fiction novelsRedDevil 4 (2014) andLimbo (2017), which explore ethical implications of neurotechnology.[1] He co-hosts the podcastBrain Coffee and created the Emmy-winning educational television seriesBrainWorks (2016).[16]
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