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Eptazocine

From Wikipedia, the free encyclopedia

Opioid analgesic

Pharmaceutical compound

Eptazocine
Clinical data


Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name (1S,6S)-1,4-dimethyl-2,3,4,5,6,7-hexahydro-1H-1,6-methano-4-benzazonin-10-ol
CAS Number	72522-13-5 72150-17-5 (bromide)
PubChemCID	3042090
ChemSpider	2305268
UNII	2208ZLI77S
ChEMBL	ChEMBL70566
CompTox Dashboard(EPA)	DTXSID501024513
Chemical and physical data
Formula	C₁₅H₂₁NO
Molar mass	231.339 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc1ccc2c(c1)[C@@]3(CCN(C[C@H](C2)C3)C)C
InChI InChI=1S/C15H21NO/c1-15-5-6-16(2)10-11(9-15)7-12-3-4-13(17)8-14(12)15/h3-4,8,11,17H,5-7,9-10H2,1-2H3/t11-,15-/m1/s1 Key:ZOWQTJXNFTWSCS-IAQYHMDHSA-N

Eptazocine (Sedapain) is anopioid analgesic which was introduced inJapan byMorishita in 1987.^[1]^[2]^[3]^[4] It acts as a mixedκ-opioid receptor agonist andμ-opioid receptor antagonist.^[4]^[5]^[6]

^Index nominum 2000: international drug directory. Taylor & Francis US. 2000. p. 396.ISBN 978-3-88763-075-1. Retrieved29 November 2011.
^American Chemical Society. Division of Medicinal Chemistry (1990)."Cumulative NCE Introduction index, 1983-189, by Indication". In Bristol JA (ed.).Annual Reports in Medicinal Chemistry. Academic Press. p. 381.ISBN 978-0-12-040525-1. Retrieved29 November 2011.
^Nabeshima T, Matsuno K, Kamei H, Kameyama T (May 1985). "The interaction of eptazocine, a novel analgesic, with opioid receptors".Research Communications in Chemical Pathology and Pharmacology.48 (2):173–181.PMID 2992058.
^^a ^bNagase H, Fujii H (21 January 2011)."Synthesis of Novel Basic Skeletons Derived from Naltrexone". In Nagase H, Calderon SN (eds.).Chemistry of Opioids. Springer. p. 280.ISBN 978-3-642-18106-1. Retrieved29 November 2011.
^Tamura T, Ogawa J, Taniguchi T, Waki I (January 1990)."[Preferential action of eptazocine, a novel analgesic, with opioid receptors in isolated guinea pig ileum and mouse vas deferens preparations]".Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese).95 (1):41–46.doi:10.1254/fpj.95.1_41.PMID 2154395.
^Morton IK, Hall JM (1999).Concise dictionary of pharmacological agents: properties and synonyms. Springer. p. 113.ISBN 978-0-7514-0499-9. Retrieved29 November 2011.

Opiates/opium	Codeine^# +aspirin +paracetamol Morphine^# (+naltrexone) Opium Laudanum Paregoric
Semisynthetic	Acetyldihydrocodeine Benzylmorphine Buprenorphine (+naloxone) Butorphanol Desomorphine Dihydrocodeine (+paracetamol) Dihydromorphine Etorphine Ethylmorphine Hydrocodone (+paracetamol,+ibuprofen,+aspirin) Hydromorphinol Hydromorphone Levorphanol Metopon Nalbuphine Nicocodeine Nicodicodine Nicomorphine Oxycodone (+paracetamol,+aspirin,+ibuprofen,+naloxone,+naltrexone) Oxymorphone Papaveretum Thebacon
Synthetic	Alfentanil Alphaprodine Anileridine Bezitramide Carfentanil Dextromoramide Dextropropoxyphene Dezocine Dimenoxadol Dipipanone Ethoheptazine Fentanyl^# (+fluanisone) Ketobemidone Lofentanil Meptazinol Methadone^# NFEPP Norpipanone Oliceridine Pentazocine Pethidine (meperidine) Phenadoxone Phenazocine Phenoperidine Piminodine Piritramide Proheptazine Propiram Remifentanil Sufentanil Tapentadol Tilidine Tramadol (+celecoxib,+paracetamol) Viminol

Propionates	Benoxaprofen^‡ Fenoprofen Flurbiprofen Ibuprofen^# (Dexibuprofen) (+paracetamol) Ketoprofen (Dexketoprofen) Loxoprofen Naproxen Oxaprozin Suprofen Tiaprofenic acid Zaltoprofen
Oxicams	Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Acetates	Acemetacin Bromfenac Diclofenac Etodolac Indometacin (Indometacin farnesil) Ketorolac Sulindac Tolmetin Zomepirac^‡
COX-2 inhibitors	Celecoxib (+tramadol) Etoricoxib Lumiracoxib^‡ Parecoxib Rofecoxib^‡ Valdecoxib^‡
Fenamates	Flufenamic acid Meclofenamic acid Mefenamic acid Tolfenamic acid
Salicylates	Aspirin (acetylsalicylic acid)^# (+paracetamol/caffeine) Aloxiprin Benorylate Carbasalate calcium Choline salicylate Diflunisal Dipyrocetyl Ethenzamide Guacetisal Imidazole salicylate Magnesium salicylate Morpholine salicylate Potassium salicylate Salicin Salicylamide Salsalate Sodium salicylate Wintergreen (methyl salicylate)
Pyrazolones	Aminophenazone^‡ Ampyrone Metamizole (dipyrone) Nifenazone Phenazone Propyphenazone (+paracetamol/caffeine)
Others	Benzydamine Floctafenine Glafenine Nabumetone Nimesulide Proquazone

Calcium blockers	Alcohol (ethanol) Gabapentin Gabapentin enacarbil Leconotide Mirogabalin Pregabalin Ziconotide
Sodium blockers	Carbamazepine Lacosamide Local anesthetics (e.g.,cocaine,lidocaine) Mexiletine Nefopam Tricyclic antidepressants (e.g.,amitriptyline^#) Na_v1.7/1.8-selective:DSP-2230^§ Funapide^§ PF-05089771^§ Suzetrigine
Potassium openers	Flupirtine^‡